rs498422

minus

Geno	Mag	Summary
(A;A)		normal risk for infertility in Chinese men
(A;C)	1.3	1.42x higher risk for infertility in Chinese men
(C;C)	1.4	>1.42x slightly higher risk for infertility in Chinese men

Reference

GRCh38 38.1/141

Chromosome

6

Position

32318984

Gene	C6orf10, LOC101929163

is a	snp
is	mentioned by
dbSNP	rs498422
dbSNP (classic)	rs498422
ClinGen	rs498422
ebi	rs498422
HLI	rs498422
Exac	rs498422
Gnomad	rs498422
Varsome	rs498422
LitVar	rs498422
Map	rs498422
PheGenI	rs498422
Biobank	rs498422
1000 genomes	rs498422
hgdp	rs498422
ensembl	rs498422
geneview	rs498422
scholar	rs498422
google	rs498422
pharmgkb	rs498422
gwascentral	rs498422
openSNP	rs498422
23andMe	rs498422
SNPshot	rs498422
SNPdbe	rs498422
MSV3d	rs498422
GWAS Ctlg	rs498422

GMAF

0.1538

Max Magnitude

1.4

rs3129878 is a SNP on chromosome 6, within a gene known as chromosomal open reading frame 10 (C6orf10). It has been associated with slightly (~40%) higher risk for azoospermia (lack of sperm) and thus male infertility in Chinese but not Japanese men.[PMID 22541561 ][PMID 23934009]

?

(A;A) (A;C) (C;C)

28

[PMID 23934009] HLA-DPB1*04:01 allele is associated with non-obstructive azoospermia in Japanese patients

[PMID 22541561 ] A genome-wide association study reveals that variants within the HLA region are associated with risk for nonobstructive azoospermia.