rs6684865

plus

Geno	Mag	Summary
(A;A)	0	1.5x risk of rheumatoid arthritis
(A;G)		1.2x risk of rheumatoid arthritis
(G;G)		normal

Reference

GRCh38 38.1/141

Chromosome

1

Position

2614790

Gene

MMEL1

is a	snp
is	mentioned by
dbSNP	rs6684865
dbSNP (classic)	rs6684865
ClinGen	rs6684865
ebi	rs6684865
HLI	rs6684865
Exac	rs6684865
Gnomad	rs6684865
Varsome	rs6684865
LitVar	rs6684865
Map	rs6684865
PheGenI	rs6684865
Biobank	rs6684865
1000 genomes	rs6684865
hgdp	rs6684865
ensembl	rs6684865
geneview	rs6684865
scholar	rs6684865
google	rs6684865
pharmgkb	rs6684865
gwascentral	rs6684865
openSNP	rs6684865
23andMe	rs6684865
SNPshot	rs6684865
SNPdbe	rs6684865
MSV3d	rs6684865
GWAS Ctlg	rs6684865

GMAF

0.4178

Max Magnitude

0

?

(A;A) (A;G) (G;G)

28

rs6684865 has been reported in a large study to be associated with rheumatoid arthritis.

The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 1.27 (CI 1.02-1.56), and for homozygotes, 1.54 (CI 1.25-1.90). [PMID 17554300 ]

[PMID 20187130] Evidence of epistasis between TNFRSF14 and TNFRSF6B polymorphisms in patients with rheumatoid arthritis

[PMID 20962851] Members 6B and 14 of the TNF receptor superfamily in multiple sclerosis predisposition

[PMID 18794857 ] Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13.

[PMID 20017963 ] Representation of genetic association via attributable familial relative risks in order to identify polymorphisms functionally relevant to rheumatoid arthritis.

[PMID 20439292] Genetic variants in the prediction of rheumatoid arthritis.