| Geno
|
Mag
|
Summary
|
| (A;A)
|
1.6
|
slight (1.4x) increase in risk for abdominal aortic aneurysm and other vascular disorders
|
| (A;G)
|
1.4
|
slight (1.2x) increase in risk for abdominal aortic aneurysm and some vascular disorders
|
| (G;G)
|
0
|
common/normal
|
rs7025486(A) was associated with up to a 20% increased risk of the various vascular diseases, with an odds ratio of 1.21 for abdominal aortic aneurysm (AAA) (p = 4.6x10-10), 1.18 for early onset myocardial infarction (MI) (p = 3.1x10-5), 1.14 for peripheral arterial disease PAD (p = 3.9x10-5), and 1.2 for pulmonary embolism (PE) (p = 00030), but it was not associated with intracranial aneurysm or ischemic stroke. [PMID 20622881
] An individual who carried two copies of this allele would have around a 44% increased risk of AAA.
No association was seen between the A allele and common risk factors for arterial and venous disease—smoking, lipid levels, obesity, type 2 diabetes, and hypertension. theheart.org
DeCode reports that the rs7025486(A;A) genotype is associated with 1.21x odds of peripheral arterial disease (PAD) [PMID 18385739] and 1.32x odds of abdominal aortic aneurysm (AAA) [PMID 20622881].
| GWAS snp
|
| PMID
|
[PMID 20622881]
|
| Trait
|
Abdominal aortic aneurysm
|
| Title
|
Genome-wide association study identifies a sequence variant with the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm
|
| Risk Allele
|
A
|
| P-val
|
5E-10
|
| Odds Ratio
|
1.21 [1.14-1.28]
|
[PMID 21444365] Association of a sequence variant in DAB2IP with coronary heart disease
[PMID 28962556] Association of the single nucleotide polymorphism in chromosome 9p21 and chromosome 9q33 with coronary artery disease in Chinese population.
] An individual who carried two copies of this allele would have around a 44% increased risk of AAA.
