rs725613

minus

Geno	Mag	Summary
(A;A)		1.2x increased type-1 diabetes risk; 1.2x increased multiple sclerosis risk
(A;C)		1.2x increased type-1 diabetes risk; 1.2x increased multiple sclerosis risk
(C;C)		normal

Reference

GRCh38 38.1/141

Chromosome

16

Position

11075826

Gene

CLEC16A

is a	snp
is	mentioned by
dbSNP	rs725613
dbSNP (classic)	rs725613
ClinGen	rs725613
ebi	rs725613
HLI	rs725613
Exac	rs725613
Gnomad	rs725613
Varsome	rs725613
LitVar	rs725613
Map	rs725613
PheGenI	rs725613
Biobank	rs725613
1000 genomes	rs725613
hgdp	rs725613
ensembl	rs725613
geneview	rs725613
scholar	rs725613
google	rs725613
pharmgkb	rs725613
gwascentral	rs725613
openSNP	rs725613
23andMe	rs725613
SNPshot	rs725613
SNPdbe	rs725613
MSV3d	rs725613
GWAS Ctlg	rs725613

GMAF

0.3714

Max Magnitude

0

?

(A;A) (A;C) (C;C)

28

[PMID 17632545] associated with type-1 diabetes

In a separate study, Sardinians with either type-1 diabetes (1,037 patients) or multiple sclerosis (1,498 patients) plus matched controls were genotyped for rs725613. In this study, the rs725613(A) allele was positively associated not only with type-1 diabetes (odds ratio 1.15, p = 5.1 x 10e-3) but also with multiple sclerosis (odds ratio = 1.21, p = 6.7 x 10e-5).[PMID 18946483]

[PMID 19178520] rs725613 was strongly associated with T1D in the Han Chinese population (P = 0.00007, odds ratio (OR) = 0.527, 95% confidence interval (CI) = 0.383-0.726)

OMIM	222100
Desc	DIABETES MELLITUS, INSULIN-DEPENDENT; IDDM
Variant
Related	also

OMIM	611303
Desc	C-TYPE LECTIN DOMAIN FAMILY 16, MEMBER A; CLEC16A
Variant
Related	also

[PMID 20849399] More CLEC16A gene variants associated with multiple sclerosis

[PMID 18840781 ] Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes.

[PMID 20405052 ] The effect of single nucleotide polymorphisms from genome wide association studies in multiple sclerosis on gene expression.

[PMID 23922971 ] Genetic associations with diabetes: meta-analyses of 10 candidate polymorphisms