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rs73568641

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 1.9 For African Americans in treatment, possible methadone dose adjustment
(C;T) 1.9 For African Americans in treatment, possible methadone dose adjustment
(T;T) 0 common/normal
ReferenceGRCh38.p7 38.3/149
Chromosome6
Position153704004
is asnp
is mentioned by
dbSNPrs73568641
dbSNP (classic)rs73568641
ClinGenrs73568641
ebirs73568641
HLIrs73568641
Exacrs73568641
Gnomadrs73568641
Varsomers73568641
LitVarrs73568641
Maprs73568641
PheGenIrs73568641
Biobankrs73568641
1000 genomesrs73568641
hgdprs73568641
ensemblrs73568641
geneviewrs73568641
scholarrs73568641
googlers73568641
pharmgkbrs73568641
gwascentralrs73568641
openSNPrs73568641
23andMers73568641
23andMe allrs73568641
SNPshotrs73568641
SNPdbers73568641
MSV3drs73568641
GWAS Ctlgrs73568641
Max Magnitude1.9

rs73568641 represents a variant located ~300kb away from the OPRM1 gene on chromosome 6.

A study of ~400 African-Americans reported a genome-wide significant association between therapeutic methadone dose as used to treat opioid dependence (mean=68.0 mg, s.d.=30.1 mg) and rs73568641 (p=2.8 × 10e−8), with each minor rs73568641(C) allele corresponding to an additional maintenance dose of ~20 mg/day (of oral methadone). This association was not seen in European-Americans.[PMID 28115739OA-icon.png]