rs7653 represents a rare variant in the SAR1A gene on chromosome 10.
A 2017 publication reports that the rs7653(C) allele may be associated with a lower odds of developing Alzheimer's disease in individuals otherwise at higher risk for the disorder. In ~400 individuals from the ADNI cohort tested, the rs7653(C) allele carriers had an odds ratio of 0.35 (p value = 0.0049) compared to non-carriers; however, in ~500 individuals from the CCS cohort subsequently tested, rs7653(C) carriers did not have a statistically significant difference from non-carriers, even though the authors reported that the association was in the "predicted positive direction". This is in contrast to the findings associated with rs142787485, which were significant in both cohorts.[PMID 29183403]
The 2017 publication describes the same research cited in a report from ICAD 2016 (page 4 and page 9 of this pdf.
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