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rs7653

From SNPedia
Orientationminus
Stabilizedminus
Geno Mag Summary
(T;T) 0 common/normal
Make rs7653(C;C)
Make rs7653(C;T)
ReferenceGRCh38.p2 38.2/147
Chromosome10
Position70150560
GeneSAR1A
is asnp
is mentioned by
dbSNPrs7653
dbSNP (old)rs7653
ClinGenrs7653
ebirs7653
HLIrs7653
Exacrs7653
Gnomadrs7653
Varsomers7653
Maprs7653
PheGenIrs7653
Biobankrs7653
1000 genomesrs7653
hgdprs7653
ensemblrs7653
gopubmedrs7653
geneviewrs7653
scholarrs7653
googlers7653
pharmgkbrs7653
gwascentralrs7653
openSNPrs7653
23andMers7653
23andMe allrs7653
SNPshotrs7653
SNPdbers7653
MSV3drs7653
GWAS Ctlgrs7653
Max Magnitude0

rs7653 represents a rare variant in the SAR1A gene on chromosome 10.

A 2017 publication reports that the rs7653(C) allele may be associated with a lower odds of developing Alzheimer's disease in individuals otherwise at higher risk for the disorder. In ~400 individuals from the ADNI cohort tested, the rs7653(C) allele carriers had an odds ratio of 0.35 (p value = 0.0049) compared to non-carriers; however, in ~500 individuals from the CCS cohort subsequently tested, rs7653(C) carriers did not have a statistically significant difference from non-carriers, even though the authors reported that the association was in the "predicted positive direction". This is in contrast to the findings associated with rs142787485, which were significant in both cohorts.[PMID 29183403OA-icon.png]

The 2017 publication describes the same research cited in a report from ICAD 2016 (page 4 and page 9 of this pdf.


? (C;C) (C;T) (T;T) 28