This SNP, a variant in the BRCA2 gene, is 1 of 25 SNPs reported to represent independently minor, but cumulatively significant, increased risk for breast cancer. [PMID 17341484]
For details of all 25 SNPs in this group, along with the two methods used to calculate overall risk estimates for breast cancer, refer to the SNPedia breast cancer entry.
For this particular SNP, the risk (minor) allele is (G).
ClinVar
|
Risk
|
rs766173(C;C) Rs766173(G;G) |
Alt
|
rs766173(C;C) Rs766173(G;G) |
Reference
|
Rs766173(T;T) |
Significance |
Probable-non-pathogenic |
Disease |
not provided Breast-ovarian cancer not specified Hereditary cancer-predisposing syndrome Fanconi anemia Hereditary breast and ovarian cancer syndrome Familial cancer of breast |
Variation | info |
---|
Gene |
BRCA2 |
CLNDBN |
not provided Breast-ovarian cancer, familial 2 not specified Hereditary cancer-predisposing syndrome Fanconi anemia Hereditary breast and ovarian cancer syndrome Familial cancer of breast |
Reversed |
1 |
HGVS |
NC_000013.10:g.32906480A>C; NC_000013.10:g.32906480A>G |
CLNSRC |
Inc. |
CLNACC |
RCV000034465.3, RCV000112858.4, RCV000120305.5, RCV000130996.3, RCV000351416.1, RCV000393165.2, RCV000470594.1, RCV000031759.4, RCV000045592.4, RCV000164485.2, RCV000441052.1, |
[PMID 16857995] Risk of non-Hodgkin lymphoma (NHL) in relation to germline variation in DNA repair and related genes.