| Geno
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Mag
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Summary
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| (C;C)
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|
normal
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| (C;T)
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|
1.20x increased breast cancer risk
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| (T;T)
|
|
1.64x increased breast cancer risk
|
rs7895676 is a SNP within intron 2 of the FGFR2 gene, as part of a haplotype associated with increased risk for sporadic postmenopausal ER+ breast cancer in Caucasian patients. The risk shown for this SNP is actually the risk calculated for the tightly associated SNP rs1219648.[PMID 17529973
]
The distinguishing feature of rs7895676 is experimental evidence indicating that it is one of two SNPs in this intron that appear to have a (the?) functional role associated with the transcriptional regulation of the FGFR2 gene. The minor alleles of both SNPs, rs7895676 and rs2981578, lead to increased transcription and increased breast cancer risk.10.1371/journal.pbio.0060108
[PMID 19536173] Association of FGFR2 gene polymorphisms with the risk of breast cancer in population of West Siberia
[PMID 18462018] Allele-specific up-regulation of FGFR2 increases susceptibility to breast cancer.
[PMID 19223389] FGFR2 variants and breast cancer risk: fine-scale mapping using African American studies and analysis of chromatin conformation.
[PMID 19434427] Analytical methods for inferring functional effects of single base pair substitutions in human cancers.
[PMID 19497954] Histone-acetylated control of fibroblast growth factor receptor 2 intron 2 polymorphisms and isoform splicing in breast cancer.
]
