rs7923837
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 0 | normal risk for T2D |
| (A;G) | 1.9 | 1.6x risk for T2D |
| (G;G) | 2 | 3.2x risk for T2D |
| Reference | GRCh38 38.1/142 |
| Chromosome | 10 |
| Position | 92722160 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs7923837 |
| dbSNP (classic) | rs7923837 |
| ClinGen | rs7923837 |
| ebi | rs7923837 |
| HLI | rs7923837 |
| Exac | rs7923837 |
| Gnomad | rs7923837 |
| Varsome | rs7923837 |
| LitVar | rs7923837 |
| Map | rs7923837 |
| PheGenI | rs7923837 |
| Biobank | rs7923837 |
| 1000 genomes | rs7923837 |
| hgdp | rs7923837 |
| ensembl | rs7923837 |
| geneview | rs7923837 |
| scholar | rs7923837 |
| rs7923837 | |
| pharmgkb | rs7923837 |
| gwascentral | rs7923837 |
| openSNP | rs7923837 |
| 23andMe | rs7923837 |
| SNPshot | rs7923837 |
| SNPdbe | rs7923837 |
| MSV3d | rs7923837 |
| GWAS Ctlg | rs7923837 |
| GMAF | 0.427 |
| Max Magnitude | 2 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
rs7923837 is a SNP of the HHEX homeobox gene. In several studies, it has been associated with risk for type-2 diabetes (T2D).
In a study of 500 unrelated Caucasian T2D patients, the rs7923837(G) allele was overrepresented; the odds ratio was 1.57 (CI: 1.08-2.27, p=0.017). In this population, the population attributable risk for this allele was estimated to be 33%.[PMID 18231124]
In a study of ~400 Japanese T2D patients, rs7923837(G) was also associated with type-2 diabetes (odds ratio 1.66, CI: 1.28-2.15, p=0.00014). Heterozygous and homozygous carriers of the risk allele had odds ratios of 1.57 (95% CI 1.15-2.16, p=0.0050) and 3.16 (95% CI 1.40-7.16, p=0.0038) relative to non-carriers.[PMID 17971426]
[PMID 18477659] rs7923837 replicated as significant for type-2 diabetes risk in 1,900 Japanese patients, with odds ratio of 1.27 (CI: 1.13-1.43, p = 1.0 x 10e-4)
[PMID 19033397
] This SNP was confirmed to be associated with type-2 diabetes in a study of 500+ Japanese patients plus pooled meta-analysis with 6 previous association studies (also of Japanese).
[PMID 19117022] rs7923837 and rs1111875 were significantly associated with decreased insulin secretion and lower insulinogenic index in a study of 420 Germans in the MESYBEOP cohort.
[PMID 20043145] Improvements in glucose homeostasis in response to regular exercise are influenced by the PPARG Pro12Ala variant: results from the HERITAGE Family Study
[PMID 20802253] Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion
[PMID 21059810] Meta-analysis of the effect of HHEX gene polymorphism on the risk of type 2 diabetes
| GWAS snp | |
|---|---|
| PMID | [PMID 21833088]
|
| Trait | |
| Title | Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. |
| Risk Allele | G |
| P-val | 5E-9 |
| Odds Ratio | 1.1000 [1.08-1.11] |
[PMID 22506066] Genetic Variants of IDE-KIF11-HHEX at 10q23.33 Associated with Type 2 Diabetes Risk: A Fine-Mapping Study in Chinese Population
[PMID 17786204] Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function.
[PMID 17928989] Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population.
[PMID 18039816] A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study.
[PMID 18162508] Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population.
[PMID 18264689] Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion.
[PMID 18426861] Association analysis of type 2 diabetes Loci in type 1 diabetes.
[PMID 18443202] Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies.
[PMID 18461161] Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value.
[PMID 18469204] Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians.
[PMID 18544707] Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program.
[PMID 18556337] Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1).
[PMID 18633108] Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population.
[PMID 18654633] Simultaneous analysis of all SNPs in genome-wide and re-sequencing association studies.
[PMID 18689899] Exchangeable models of complex inherited diseases.
[PMID 19002430] Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population.
[PMID 19172244] The risk allele load accelerates the age-dependent decline in beta cell function.
[PMID 19368707] Contribution of type 2 diabetes associated loci in the Arabic population from Tunisia: a case-control study.
[PMID 19741467] Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea.
[PMID 19933996] Examination of all type 2 diabetes GWAS loci reveals HHEX-IDE as a locus influencing pediatric BMI.
[PMID 20080751] Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3.
[PMID 20126254] Rare variants create synthetic genome-wide associations.
[PMID 20532014] The epidemiology of diabetes in Korea: from the economics to genetics.
[PMID 20550665] Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population.
[PMID 20580033] Replication of recently described type 2 diabetes gene variants in a South Indian population.
[PMID 21278902] Genetic risk profiling for prediction of type 2 diabetes.
[PMID 24468095] Genetic variants for type 2 diabetes and new-onset cancer in Chinese with type 2 diabetes
[PMID 22923468] Contribution of common genetic variation to the risk of type 2 diabetes in the Mexican Mestizo population.
[PMID 23458876] ACE I/D and MTHFR C677T polymorphisms are significantly associated with type 2 diabetes in Arab ethnicity: a meta-analysis.
