rs9263726

plus

Geno	Mag	Summary
(A;A)	3	In Japanese populations, associated with HLA-B*5801 allele and allopurinol side effects
(A;G)	3	In Japanese populations, associated with HLA-B*5801 allele and allopurinol side effects
(G;G)	0	common/normal

Reference

GRCh38 38.1/141

Chromosome

6

Position

31138722

Gene	PSORS1C1, PSORS1C2

is a	snp
is	mentioned by
dbSNP	rs9263726
dbSNP (classic)	rs9263726
ClinGen	rs9263726
ebi	rs9263726
HLI	rs9263726
Exac	rs9263726
Gnomad	rs9263726
Varsome	rs9263726
LitVar	rs9263726
Map	rs9263726
PheGenI	rs9263726
Biobank	rs9263726
1000 genomes	rs9263726
hgdp	rs9263726
ensembl	rs9263726
geneview	rs9263726
scholar	rs9263726
google	rs9263726
pharmgkb	rs9263726
gwascentral	rs9263726
openSNP	rs9263726
23andMe	rs9263726
SNPshot	rs9263726
SNPdbe	rs9263726
MSV3d	rs9263726
GWAS Ctlg	rs9263726

GMAF

0.1139

Max Magnitude

3

?

(A;A) (A;G) (G;G)

28

The minor allele of this SNP, rs9263726, is reported to 100% predictive of the presence of an HLA-B*58:01 allele, at least in Japanese populations, and therefore also of greatly increased risk for HLA-B*58:01 related susceptibilities. An example of such a susceptibility is the greatly (>50X) increased odds of developing severe side effects from taking allopurinol.[PMID 21912425]

[PMID 21912425] A whole-genome association study of major determinants for allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients

[PMID 33356553] Genetic susceptibilities and prediction modeling of carbamazepine and allopurinol-induced severe cutaneous adverse reactions in Vietnamese.