| Geno
|
Mag
|
Summary
|
| (C;C)
|
3
|
3x increased risk for developing a peanut allergy, 0.54x risk of IgA Nephropathy in Chinese
|
| (C;T)
|
1.7
|
1.7x increased risk for developing a peanut allergy, 0.54x risk of IgA Nephropathy in Chinese
|
| (T;T)
|
0
|
common/normal
|
rs9275596 is a SNP located between the HLA-DQB1 and HLA-DQA2 genes on chromosome 6.
A study of several thousand children and their parents, most with food allergies, concluded that two SNPs, rs7192 and rs9275596, are associated with increased susceptibility to developing a peanut allergy in populations of European ancestry. The odds ratio reported for rs9275596(C) were 1.7 (p=10e-10).[PMID 25710614
]
| GWAS snp
|
| PMID
|
[PMID 21399633]
|
| Trait
|
|
| Title
|
Genome-wide association study identifies susceptibility loci for IgA nephropathy
|
| Risk Allele
|
|
| P-val
|
2E-26
|
| Odds Ratio
|
1.5900 [NR]
|
[PMID 18204098] Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.
[PMID 19010793] Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.
[PMID 20018067] A two-stage search strategy for detecting multiple loci associated with rheumatoid arthritis.
Kidney Disease
[PMID 28929317] Risk alleles for IgA nephropathy-associated SNPs conferred completely opposite effects to idiopathic membranous nephropathy in Chinese Han.
[PMID 32244438] An Intergenic rs9275596 Polymorphism on Chr. 6p21 Is Associated with Multiple Sclerosis in Latvians.
[PMID 33175217] Association of HLA-DQ and IL13 gene variants with challenge-proven shrimp allergy in West Bengal, India.
]
