Variant in the NOD2 gene associated with greater susceptibility to leprosy in Asians, according to the 23andMe blog. The risk allele is C, and the odds ratio is 1.59.
Another gene associated with susceptibility to leprosy is TNFSF15. SNPs in both the NOD2 and TNFSF15 genes are also associated with susceptibility to Crohn's disease.
| GWAS snp
|
| PMID
|
[PMID 20018961]
|
| Trait
|
Leprosy
|
| Title
|
Genomewide Association Study of Leprosy
|
| Risk Allele
|
G
|
| P-val
|
4E-40
|
| Odds Ratio
|
1.59 [1.49-1.71]
|
[PMID 22212192] Polymorphisms of NOD2 and the risk of tuberculosis: a validation study in the Chinese population
[PMID 22504414] Association between C13ORF31, NOD2, RIPK2 and TLR10 polymorphisms and urothelial bladder cancer.
Leprosy Susceptibility
[PMID 27128681
] Genetic Variation in Autophagy-Related Genes Influences the Risk and Phenotype of Buruli Ulcer.
] Genetic Variation in Autophagy-Related Genes Influences the Risk and Phenotype of Buruli Ulcer.
