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rs9574

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) EPCR H1 diplotype; reduced risk of VTE?
(C;G) EPCR H1 haplotype; reduced risk of VTE?
(G;G) normal risk for VTE
ReferenceGRCh38 38.1/141
Chromosome20
Position35176829
GenePROCR
is asnp
is mentioned by
dbSNPrs9574
dbSNP (classic)rs9574
ClinGenrs9574
ebirs9574
HLIrs9574
Exacrs9574
Gnomadrs9574
Varsomers9574
LitVarrs9574
Maprs9574
PheGenIrs9574
Biobankrs9574
1000 genomesrs9574
hgdprs9574
ensemblrs9574
geneviewrs9574
scholarrs9574
googlers9574
pharmgkbrs9574
gwascentralrs9574
openSNPrs9574
23andMers9574
SNPshotrs9574
SNPdbers9574
MSV3drs9574
GWAS Ctlgrs9574
GMAF0.449
Max Magnitude0
? (C;C) (C;G) (G;G) 28


rs9574 is a SNP that can indicate haplotype H1 of the PROCR gene. The protein product of the PROCR gene activates a part of the anticoagulation pathway. While the rs9574(G) allele could indicate haplotypes H2, H3 or H4, the rs9574(C) allele distinctly tags (identifies) the H1 haplotype.[PMID 17849044]

The H1 haplotype (and thus rs9574(C)) has been reported to be associated with a reduced risk of venous thromboembolism (VTE), with an odds ratio of 0.59, CI: 0.41–0.84.[PMID 15116250] Two other groups have not found this association to be statistically valid in the populations they studied.[PMID 14576048, PMID 15304035]


[PMID 30383853OA-icon.png] Genetics of the thrombomodulin-endothelial cell protein C receptor system and the risk of early-onset ischemic stroke.