||EPCR H1 diplotype; reduced risk of VTE?
||EPCR H1 haplotype; reduced risk of VTE?
||normal risk for VTE
rs9574 is a SNP that can indicate haplotype H1 of the PROCR gene. The protein product of the PROCR gene activates a part of the anticoagulation pathway. While the rs9574(G) allele could indicate haplotypes H2, H3 or H4, the rs9574(C) allele distinctly tags (identifies) the H1 haplotype.[PMID 17849044]
The H1 haplotype (and thus rs9574(C)) has been reported to be associated with a reduced risk of venous thromboembolism (VTE), with an odds ratio of 0.59, CI: 0.41â€“0.84.[PMID 15116250] Two other groups have not found this association to be statistically valid in the populations they studied.[PMID 14576048, PMID 15304035]
[PMID 30383853] Genetics of the thrombomodulin-endothelial cell protein C receptor system and the risk of early-onset ischemic stroke.