TPH1
From SNPedia
| is a | gene |
| is | mentioned by |
| Full name | tryptophan hydroxylase 1 |
| Other names | TPH |
| EntrezGene | 7166 |
| PheGenI | 7166 |
| VariationViewer | 7166 |
| ClinVar | TPH1 |
| GeneCards | TPH1 |
| dbSNP | 7166 |
| Diseases | TPH1 |
| SADR | 7166 |
| HugeNav | 7166 |
| wikipedia | TPH1 |
| TPH1 | |
| gopubmed | TPH1 |
| EVS | TPH1 |
| HEFalMp | TPH1 |
| MyGene2 | TPH1 |
| 23andMe | TPH1 |
| UniProt | P17752 |
| Ensembl | ENSG00000129167 |
| OMIM | 191060 |
| # SNPs | 7 |
| Max Magnitude | Chromosome position | Summary | |
|---|---|---|---|
| rs1799913 | 1.1 | 18,025,708 | heroin addiction in hispanics |
| rs1800532 | 0 | 18,026,269 | |
| rs2108977 | 0 | 18,019,049 | |
| rs211105 | 0 | 18,033,757 | |
| rs623580 | 0 | 18,042,430 | |
| rs684302 | 0 | 18,038,806 | |
| rs7933505 | 0 | 18,024,440 |
rs211105, rs1800532 and rs7933505 related to schizophrenia
[PMID 14681922] and suicidal behavior
TPH1 is the rate-limiting biosynthetic enzyme for serotonin in enterochromaffin cells of the duodenum. Expression of TPH1 is inhibited by [1] LRP5. It has been observed that this decreased serotonin blood level normalizes bone formation and bone mass in LRP5-deficient mice.
