As a fluoropyrimidine, several genes (notably the DPYD and TPMT genes) are known to harbor nonfunctional alleles that predispose individuals administered tegafur to potentially severe or even fatal toxicity.
|Normal Response Expected
|You do not appear to carry any DPYD mutations linked to adverse side effects from tegafur use.
|Consider Half-Dose and/or Pharmacokinetic Studies
|You carry a nonfunctional DPYD allele that increases your risk for a toxicity upon tegafur administration; consider starting at half-dose and/or doing pharmacokinetic studies.
|Avoid 5-FU; use an alternative drug
|You may be at very high risk for severe toxicity from tegafur administration; all major drug regulatory agencies recommend you select a non-fluoropyrimidine alternative chemotherapeutic.