rs11172113

plus

Geno	Mag	Summary
(C;C)	1.2	0.8x lower risk for migraines
(C;T)	1.1	0.9x lower risk for migraines

Make rs11172113(T;T)

Reference

GRCh38 38.1/141

Chromosome

12

Position

57133500

Gene

LRP1

is a	snp
is	mentioned by
dbSNP	rs11172113
dbSNP (classic)	rs11172113
ClinGen	rs11172113
ebi	rs11172113
HLI	rs11172113
Exac	rs11172113
Gnomad	rs11172113
Varsome	rs11172113
LitVar	rs11172113
Map	rs11172113
PheGenI	rs11172113
Biobank	rs11172113
1000 genomes	rs11172113
hgdp	rs11172113
ensembl	rs11172113
geneview	rs11172113
scholar	rs11172113
google	rs11172113
pharmgkb	rs11172113
gwascentral	rs11172113
openSNP	rs11172113
23andMe	rs11172113
SNPshot	rs11172113
SNPdbe	rs11172113
MSV3d	rs11172113
GWAS Ctlg	rs11172113

GMAF

0.3898

Max Magnitude

1.2

?

(C;C) (C;T) (T;T)

28

rs11172113 is a SNP on ch 12q13.3 in the LRP1 gene.

A large GWAS study of over 5,000 patients with migraines and a meta-analysis concluded that this SNP was one of three influencing the condition, albeit with only slight risk changes on its own. The odds ratio for the less common rs11172113(C) allele was 0.9 (CI: 0.87 - 0.93, p = 4.3 x 10e-9).10.1038/ng.856

GWAS snp
PMID	[PMID 21666692 ]
Trait
Title	Genome-wide association study reveals three susceptibility loci for common migraine in the general population.
Risk Allele	T
P-val	4E-9
Odds Ratio	1.1100 [1.08-1.15]

[PMID 22072275 ] Genetics of migraine in the age of genome-wide association studies

GWAS snp
PMID	[PMID 21946350 ]
Trait
Title	Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.
Risk Allele	T
P-val	1E-8
Odds Ratio	0.0320 [0.020-0.044] unit decrease

GWAS snp
PMID	[PMID 22683712 ]
Trait
Title	Genome-wide association analysis identifies susceptibility loci for migraine without aura.
Risk Allele
P-val	3E-8
Odds Ratio	1.1600 None

GWAS snp
PMID	[PMID 23284291 ]
Trait	Pulmonary function (interaction)
Title	Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
Risk Allele
P-val	8E-6
Odds Ratio	NR NR

[PMID 24021092] PRDM16 rs2651899 Variant Is a Risk Factor for Chinese Common Migraine Patients

[PMID 23294458] Replication and meta-analysis of common variants identifies a genome-wide significant locus in migraine

GWAS snp
PMID	[PMID 23793025 ]
Trait	Migraine
Title	Genome-wide meta-analysis identifies new susceptibility loci for migraine.
Risk Allele
P-val	4E-19
Odds Ratio	1.11 [1.09-1.14]

[PMID 24674449 ] A replication study of GWAS findings in migraine identifies association in a Swedish case-control sample

[PMID 30256423] Using a Genetic Risk Score Approach to Predict Headache Response to Triptans in Migraine Without Aura.