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CLOCK

From SNPedia

is agene
is mentioned by
Full nameclock homolog (mouse)
EntrezGene9575
PheGenI9575
VariationViewer9575
ClinVarCLOCK
dbSNP9575
SADR9575
HugeNav9575
wikipediaCLOCK
googleCLOCK
gopubmedCLOCK
EVSCLOCK
HEFalMpCLOCK
MyGene2CLOCK
23andMeCLOCK
UniProtO15516
EnsemblENSG00000134852
OMIM601851
# SNPs15
 Max MagnitudeChromosome positionSummary
rs1046202855,432,133
rs1124055,453,183
rs1193259555,457,430
rs1264950755,514,317
rs155448355,455,650
rs1801260255,435,202
rs19251803855,547,195
rs241264655,452,605
rs373654455,443,825
rs374947455,434,518
rs381744455,509,814
rs458070455,460,540
rs4864548055,547,636discrepancy in risk assignment
rs683276955,432,027
rs685583755,453,077

As with a symphony orchestra, the circadian orchestra is hierarchically organized, with the suprachiasmatic nucleus (SCN) of hypothalamus as its conductor. Circadian rhythm is generated by a transcriptional–translational feedback loop between two groups of clock genes: positive and negative elements. The circadian locomotor output cycles kaput (CLOCK) and the brain and muscle aryl hydrocarbon receptor nuclear translocator-like (BMAL1), acting as positive elements, are responsible of the synthesis of two transcriptional factors, which after heterodimerization induce the expression of negative components of the molecular circadian clock such as periods (Pers 1, 2 and 3), cryptochromes (Cry1 and Cry2) and nuclear receptor subfamily 1 (REV-ERB-?). These negative elements, after dimerization (PER–CRY) undergo a nuclear translocation and act as suppressors of CLOCK and BMAL1 expression. Thus, the levels of positive and negative elements oscillate in antiphase with a period of approximately 24 h in SCN in vitro.

Some components of the molecular clock, such as REV-ERB-?, BMAL1 and CLOCK also induce a number of extra-clock genes, termed clock-controlled genes (CCG), which are not directly involved in the clock machinery but are able to induce the expression of many target genes.

reference: http://www.medscape.com/viewarticle/721923_4