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EDAR

From SNPedia

is agene
is mentioned by
Full nameectodysplasin A receptor
EntrezGene10913
PheGenI10913
VariationViewer10913
ClinVarEDAR
dbSNP10913
SADR10913
HugeNav10913
wikipediaEDAR
googleEDAR
gopubmedEDAR
EVSEDAR
HEFalMpEDAR
MyGene2EDAR
23andMeEDAR
UniProtQ9UNE0
EnsemblENSG00000135960
OMIM604095
# SNPs14
 Max MagnitudeChromosome positionSummary
rs1219084500108,929,288
rs1219084510108,929,295
rs1219084520108,897,182
rs1219084530108,896,995
rs1219084540108,897,130
rs1219084550108,929,225
rs1219084560108,897,194
rs2606300108,910,917
rs365060108,959,280
rs38277602108,897,145
rs7478066720108,897,110
rs7970444350108,930,963
rs797044436108,910,784
rs7970444370108,910,459


The EDAR gene encodes the ectodysplasin A receptor, a member of the tumor necrosis factor receptor family. As this protein is required for the development of hair, teeth, and other ectodermal derivatives, mutations can result in both autosomal dominant and recessive forms of ectodermal dysplasia.Wikipedia

At least one particular SNP in the EDAR gene is also notable for having apparently experienced strong natural selection pressure in a large population, based on the analysis of over 3 million polymorphisms from the International HapMap Project Phase 2.[1] More specifically, both the EDAR and EDA2R genes are involved in a common biologic process, hair development, and both have undergone positive selection in Asians. The canonical SNP in EDAR for this is rs3827760.