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EIF4G1

From SNPedia

is agene
is mentioned by
Full nameeukaryotic translation initiation factor 4 gamma, 1
EntrezGene1981
PheGenI1981
VariationViewer1981
ClinVarEIF4G1
GeneCardsEIF4G1
dbSNP1981
SADR1981
HugeNav1981
wikipediaEIF4G1
googleEIF4G1
gopubmedEIF4G1
EVSEIF4G1
HEFalMpEIF4G1
MyGene2EIF4G1
23andMeEIF4G1
UniProtQ04637
EnsemblENSG00000114867
OMIM600495
# SNPs8
 Max MagnitudeChromosome positionSummary
rs1112909368184,322,089Late-onset Parkinson's disease
rs1120191255184,323,209
rs1121764508184,327,401Parkinson's disease
rs1131690495184,327,277
rs1133882425184,327,376
rs13319149184,319,745
rs2178403184,321,878
rs2230571184,328,682

The eIF4G1 gene encodes a protein that is the core scaffold of a multisubunit translation initiation complex that regulates the translation initiation of mRNAs encoding mitochondrial, cell survival and growth genes in response to different stresses.

Variants in this gene have recently (2011) been linked to a form of late-onset, dominant, familial Parkinson's disease.