FGFR2
From SNPedia
| is a | gene |
| is | mentioned by |
| wikipedia | FGFR2 |
| FGFR2 | |
| gopubmed | FGFR2 |
| 23andMe | FGFR2 |
dbSNP 2263
PubMed 2263
SADR 2263
HugeNav 2263
HEFalMp FGFR2
| Chromosome position | Summary | |
|---|---|---|
| Rs11200014 | 123324919123,324,919 | |
| Rs1219648 | 123336179123,336,179 | |
| Rs2420946 | 123341313123,341,313 | |
| Rs2981578 | 123330300123,330,300 | |
| Rs2981579 | 123327324123,327,324 | |
| Rs2981582 | 123342306123,342,306 | |
| Rs3135718 | 123343858123,343,858 | |
| Rs7895676 | 123323986123,323,986 |
A relatively small increase in risk for sporadic postmenopausal ER+ breast cancer in European women has been reported to be highly significant for a haplotype of intron 2 of the FGFR2 gene.[PMID 17529973]
The primary SNP associated with this risk is rs1219648, however more recently, two neighboring SNPs (rs2981578 and rs7895676) from this same region have been postulated based on experimental evidence to be the causative factors. The minor alleles of these SNPs appear to increase FGFR2 expression and thereby to increase the risk for breast cancer.10.1371/journal.pbio.0060108
blog snps in COL11A1, LMNA, FGFR1, FGFR2, TRPS, BRAF, FLNA affect normal variation in facial features.
