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FGFR2

From SNPedia

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# SNPs65
 Max MagnitudeChromosome positionSummary
rs1047100121,538,644
rs10510097121,568,362
rs10736303121,574,943
rs1078806121,579,461
rs11199993121,531,750
rs11200012121,572,901
rs11200014121,575,416
rs1219134770121,515,289
rs1219134780121,515,280
rs1219184870121,517,378
rs1219184880121,517,379
rs1219184890121,517,385
rs1219184900121,517,342
rs1219184910121,517,371
rs1219184920121,517,372
rs1219184930121,517,420
rs1219184940121,517,363
rs1219184950121,517,382
rs1219184960121,517,377
rs1219184970121,520,052
rs1219184980121,520,162
rs1219184990121,520,048
rs1219185000121,520,044
rs1219185010121,520,050
rs1219185020121,517,351
rs1219185030121,520,099
rs1219185040121,517,460
rs1219185050121,520,119
rs1219185060121,496,701
rs1219185070121,498,591
rs1219185080121,488,035
rs1219185090121,488,095
rs1219185100121,517,441
rs12196482.1121,586,676
rs17102287121,590,677
rs17542768121,578,300
rs23035680121,564,448
rs24209462.1121,591,810
rs2818654200121,520,161
rs2912774121,589,148
rs2912791121,559,447
rs2981575121,586,602
rs2981578121,580,797
rs2981579121,577,821
rs29815823.2121,592,803T allele increases risk of breast cancer
rs3135718121,594,355
rs3135730121,566,280
rs3135753121,521,144
rs3135831121,477,406
rs35054928121,580,918
... further results


A relatively small increase in risk for sporadic postmenopausal ER+ breast cancer in European women has been reported to be highly significant for a haplotype of intron 2 of the FGFR2 gene.[PMID 17529973]

The primary SNP associated with this risk is rs1219648, however more recently, two neighboring SNPs (rs2981578 and rs7895676) from this same region have been postulated based on experimental evidence to be the causative factors. The minor alleles of these SNPs appear to increase FGFR2 expression and thereby to increase the risk for breast cancer.10.1371/journal.pbio.0060108


blog snps in COL11A1, LMNA, FGFR1, FGFR2, TRPS, BRAF, FLNA affect normal variation in facial features.