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HLA-E

From SNPedia

is agene
is mentioned by
Full namemajor histocompatibility complex, class I, E
EntrezGene3133
PheGenI3133
VariationViewer3133
ClinVarHLA-E
dbSNP3133
SADR3133
HugeNav3133
wikipediaHLA-E
googleHLA-E
gopubmedHLA-E
EVSHLA-E
HEFalMpHLA-E
MyGene2HLA-E
23andMeHLA-E
UniProtP13747
EnsemblENSG00000204592
OMIM143010
# SNPs3
 Max MagnitudeChromosome positionSummary
rs105951030,489,955
rs126445730,490,287
rs126445930,488,143


HLA-E is gene for a non-classical HLA antigen, with 2 functional variants. It has been connected to multiple cancer prognoses.

HLA-E*0103X is associated with susceptibility to Pemphigus vulgaris and Behcet's disease. E *0101/*0103X is associated with childhood onset diabetes[PMID 23362868]

HLA-E*0101 was associated with hepatitis C clearance in HIV patients with interaction of rs8099917. [PMID 23811951]

HLA-E O1:01 and HLA-E 01:03 have been connected to psoriasis, dependent on HLA-C.[PMID 24279916]

HLA-E genotype was associated with CMV infection after bone marrow transplant [PMID 23998599].

HLA-E*0103/0103 may be protective in allogeneic hematopoietic stem cell transplant [PMID 23395341].