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LRP5

From SNPedia

is agene
is mentioned by
Full namelow density lipoprotein receptor-related protein 5
EntrezGene4041
PheGenI4041
VariationViewer4041
ClinVarLRP5
GeneCardsLRP5
dbSNP4041
SADR4041
HugeNav4041
wikipediaLRP5
googleLRP5
gopubmedLRP5
EVSLRP5
HEFalMpLRP5
MyGene2LRP5
23andMeLRP5
UniProtO75197
EnsemblENSG00000162337
OMIM603506
# SNPs51
 Max MagnitudeChromosome positionSummary
rs121908660068,312,743
rs121908661068,386,582
rs121908662068,409,973
rs121908663068,413,742
rs121908664068,389,949
rs121908665068,403,606
rs121908666068,389,921
rs121908667068,410,024
rs121908668068,357,673
rs121908669068,357,672
rs121908670068,363,784
rs121908671068,357,801
rs121908672068,357,802
rs121908673068,363,818
rs121908674068,410,076
rs149645175068,448,822
rs2306862068,410,042
rs2893970868,410,076
rs28939709068,436,987
rs37362281.768,433,827
rs397514663068,403,553
rs397514664068,386,445
rs397514665068,363,791
rs41494349068,348,021
rs49134768,402,220
rs498830068,321,363
rs4988321068,406,721
rs52559268,427,636
rs59908368,424,878
rs61889560068,423,568
rs63400868,327,273
rs766589610068,357,846
rs770383372068,357,661
rs80358305068,348,188
rs80358306068,357,679
rs80358307068,363,863
rs80358308068,386,630
rs80358309068,390,032
rs80358310068,403,502
rs80358311068,403,546
rs80358312068,403,607
rs80358313068,406,550
rs80358314068,406,572
rs80358315068,410,124
rs80358316068,411,509
rs80358317068,425,226
rs80358318068,426,052
rs80358319068,433,642
rs80358320068,436,969
rs80358321068,438,453
... further results

SNPs in the low-density lipoprotein receptor-related protein 5 LRP gene has been associated with several conditions, most notably:

[1] LRP5 inhibits expression of TPH1, the rate-limiting biosynthetic enzyme for serotonin in enterochromaffin cells of the duodenum. It has been observed that this decreased serotonin blood level normalizes bone formation and bone mass in LRP5-deficient mice. Futhermore, LRP5 inactivation decreases bone formation in a beta-Catenin-independent manner (Serotonin in Gut is Crucial to Bone Formation).