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MICA

From SNPedia

is agene
is mentioned by
Full nameMHC class I polypeptide-related sequence A
EntrezGene100507436
PheGenI100507436
VariationViewer100507436
ClinVarMICA
GeneCardsMICA
dbSNP100507436
SADR100507436
HugeNav100507436
wikipediaMICA
googleMICA
gopubmedMICA
EVSMICA
HEFalMpMICA
MyGene2MICA
23andMeMICA
UniProtQ29983
EnsemblENSG00000204520
OMIM600169
# SNPs15
 Max MagnitudeChromosome positionSummary
rs105179231,411,200
rs105179431,411,332
rs106363531,412,154
rs11429179531,409,863
rs1217548931,409,810
rs225618331,412,752
rs225618431,412,806
rs230174731,403,810
rs259653831,400,855
rs259654231,398,818
rs284871631,420,190
rs312898231,449,414
rs3763288031,402,590
rs4349859331,398,010
rs4418214031,423,624


The MICA gene encodes the highly polymorphic MHC class I polypeptide-related sequence A.Wikipedia

MICA is located within the human leukocyte antigen (HLA/MHC) locus, and its exon5 coding transmembrane (TM) region contains a polymorphic microsatellite, classified according to the number of alanine-encoding GCT repeats as A4, A5, A5.1, A6 and A9. A single nucleotide polymorphism (SNP) at codon 129 in exon 3 of the MICA gene, Val129Met or V129M (rs1051792), has been shown to modulate the affinity of MICA to the NKG2D receptor.