Morphine

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Morphine is a highly potent opiate analgesic drug and is the principal active agent in opium and the prototypical opioid.Wikipedia

SNPs have been identified that influence the response to morphine.


  • A study of 145 Italian patients found that pain relief variability from morphine treatment was significantly (p<0.0001) associated with polymorphisms in both the ABCB1 and OPRM1 genes. Combining the extreme genotypes of both genes, the association between patient polymorphism and pain relief improved (p<0.00001), allowing the detection of three groups: strong responders, responders, and non-responders, with sensitivity close to 100% and specificity more than 70%.[PMID 17898703]
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