Some genes are read in the reverse direction, and as a result SNPs are sometimes reported reversed. This happens quite often, as 23andMe will report genotypes on the minus, while SNPedia and dbSNP tend to only report genotypes relative to the plus strand. Making it even more confusing, occasionally snps are flipped between genome versions (ie rs17602729).
Each rs# in SNPedia has a field along the right side called 'Orientation.
If the value is 'minus' you need to change:
This leads to some ambiguous flips.
When needed, Promethease correctly flips genotypes from 23andMe's minus orientation into SNPedia's plus orientation.
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