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PTEN

From SNPedia

is agene
is mentioned by
Full namephosphatase and tensin homolog
EntrezGene5728
PheGenI5728
VariationViewer5728
ClinVarPTEN
GeneCardsPTEN
dbSNP5728
SADR5728
HugeNav5728
wikipediaPTEN
googlePTEN
gopubmedPTEN
EVSPTEN
HEFalMpPTEN
MyGene2PTEN
23andMePTEN
UniProtP60484
EnsemblENSG00000171862
OMIM601728
# SNPs202
 Max MagnitudeChromosome positionSummary
rs104894184087,952,159
rs1049092087,925,886
rs121909218087,933,145
rs121909219087,957,915
rs121909220087,933,228
rs121909221087,952,135
rs121909222087,933,127
rs121909223087,933,129
rs121909224087,933,147
rs121909225087,894,049
rs121909226087,925,557
rs121909227087,957,858
rs121909228087,957,984
rs121909229087,933,148
rs121909230087,933,094
rs121909231087,961,095
rs121909232087,952,258
rs121909233087,864,524
rs121909234087,957,867
rs121909235087,957,919
rs121909236087,925,529
rs121909237087,933,121
rs121909238087,933,037
rs121909239087,957,973
rs121909240087,957,940
rs121909241087,933,154
rs121913289087,958,018
rs121913290087,864,486
rs121913292087,933,148
rs121913293087,952,142
rs121913294087,952,143
rs123422487,915,539
rs1235728187,940,914
rs1256999887,914,400
rs146650273087,961,047
rs1743118487,960,494
rs202004587087,931,071
rs229993987,897,393
rs267383687,880,205
rs273534387,945,672
rs3442166087,916,559
rs371387815087,960,984
rs375709098087,965,321
rs383067587,931,197
rs397514559087,952,125
rs397514560087,933,151
rs397515374087,952,159
rs398123315087,965,300
rs398123316087,925,530
rs398123317087,925,550
... further results

Along with the Androgen Receptor (AR), increasing expression of this gene increases the risk of breast cancer while reducing the risk of prostate cancer and vice versa. 10.1038/onc.2011.144

The New York Times reports that mutations in the PTEN gene may cause both tuberous sclerosis and autism. Clinical trials are under way to determine whether the same drugs can be used to treat both conditions.

10.1056/NEJMoa1113966 NEJM PTEN Mutations as a Cause of Constitutive Insulin Sensitivity and Obesity