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User:JohnLloydScharf/Affective Disorders-General

From SNPedia

Affective Disorders-General[edit]






"rs950809","10","108785365","AG"
"rs10884402","10","108782932","AG"

Endophine/Opiod Receptors[edit]

  • rs1799971","6","154402490","AG"
The rs1799971(G) allele in exon 1 of the mu opioid receptor OPRM1 gene causes the normal amino acid at residue 40, asparagine (Asn), to be replaced by aspartic acid (Asp). In the literature this SNP is also known as A118G, N40D, or Asn40Asp.
Carriers of at least one rs1799971(G) allele appear to have stronger cravings for alcohol than carriers of two rs1799971(A) alleles, and are thus hypothesized to be more at higher risk for alcoholism. [PMID 17207095]


Dopamine Receptors[edit]

  • Implicated as part of a haplotype of the dopamine D1 receptor DRD1 gene associated with autism spectrum disorders in families having only affected males. The haplotype is rs265981(C)-rs4532(A)-rs686(T) as published, though not necessarily as oriented in dbSNP.[PMID 18205172]

"rs265981","5","174803508","AA" Least Common Haplotype "rs4532","5","174802756","CC" "rs686","5","174801306","GG"

-
"rs11746641","5","174798697","TT"
Most Common Haplotype
"rs1799914","5","174802511","CC"=GG Orientation minus
Most Common Haplotype.
"rs5326","5","174802802","CC"=GG Orientation minus
Most Common Haplotype.


Oxytocin[edit]

  • In humans, oxytocin has been found to enhance trust and the ability to interpret the emotions of others.
http://www.dormivigilia.com/wp-content/uploads/2009/12/Oxytocin-increases-gaze-to-the-eye-region-of-human-faces.pdf
"rs1042778","3","8769545","GG"
"rs237887","3","8772042","AG"
"rs2268490","3","8772085","TC"
"rs11706648","3","8771547","AA"
-rs13316193-- 3-- 8777743-- TT
"rs237885","3","8770543","TT"
"rs237887","3","8772042","AG"
"rs237889","3","8777483","TC"
-rs237895-- 3-- 8782423-- TC
"rs237897","3","8783285","AG"
"rs237899","3","8783515","AG"
"rs4686301","3","8773586","CC"
http://en.wikipedia.org/wiki/Oxytocin

Bipolar[edit]


  • Along with rs6442925 and rs534654, this SNP, rs1534891, is part of a 3-SNP (multi-locus) interaction that is associated with bipolar disorder.[PMID 18228528]
"rs1534891","22","37025045","CC" Most Common Allele
http://www.snpedia.com/index.php/Rs1534891
"rs6442925","3","4988876","CC" Most Common Allele
http://www.snpedia.com/index.php/Rs6442925
"rs534654","4","55984977","GG"=CC Orientation minus = Most Common Allele
http://www.snpedia.com/index.php/Rs534654


  • "rs1170191","13","41573493","GG"=CC Orientation minus Most Common among non-Asian
http://www.snpedia.com/index.php/Rs1170191


  • "rs2159100","12","2216654","TC" spittoon ([PMID 18711365]) rs1006737 or (rs2159100)
Each T at this SNP increased the odds of bipolar disorder by 1.18 times compared to having two CC copies
http://www.snpedia.com/index.php/Rs2159100


  • "rs7757037","6","35656214","GG"
rs7757037(A;A) 0.63x decreased risk for bipolar disorder
rs7757037(A;G) 0.68x decreased risk for bipolar disorder
rs7757037(G;G) normal
http://www.snpedia.com/index.php/Rs7757037
  • "rs4825476","X","122269160","AA"
This SNP, located in an intron of the GRIA3 gene (also known as AMPA3), has been linked in one study to increased thoughts of suicide in patients taking the anti-depressant drug citalopram. The increased risk is calculated to be 1.9x. If the individual is also carrying two rs2518224(C) alleles, i.e. is a rs2518224(C;C) homozygote, the odds ratio for having suicidal thoughts is increased to ~15x (CI: 3.7 - 60.6). [PharmGKB:Curated This SNP in the GRIA3 gene was associated with treatment-emergent suicidal ideation during citalopram therapy in a clinically representative cohort of outpatients with major depressive disorder. DNA samples from 1,915 participants were genotyped.] [PMID 17898344]

http://www.snpedia.com/index.php/Rs4825476

  • rs4948418 10 61855500 CC-is MOST COMMON ALLELE OF POPULATIONS
Each T at this SNP increased the odds of developing bipolar disorder by 1.45 times compared to the CC genotype.
http://www.snpedia.com/index.php/Rs4948418
http://spittoon.23andme.com/2008/08/18/snpwatch-snps-in-ion-channel-genes-are-associated-with-type-2-diabetes-and-bipolar-disorder/ Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703780/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703780/pdf/ukmss-27163.pdf
http://www.ncbi.nlm.nih.gov/pubmed/21395576


  • "rs1799971","6","154402490","AG" =2.5 stronger cravings for alcohol. If alcoholic, naltrexone treatment 2x more successful
    • The rs1799971(G) allele in exon 1 of the mu opioid receptor OPRM1 gene causes the normal amino acid at residue 40, asparagine (Asn), to be replaced by aspartic acid (Asp). In the literature this SNP is also known as A118G, N40D, or Asn40Asp.
      Carriers of at least one rs1799971(G) allele appear to have stronger cravings for alcohol than carriers of two rs1799971(A) alleles, and are thus hypothesized to be more at higher risk for alcoholism. [PMID 17207095]
http://www.snpedia.com/index.php/Rs1799971(A;G)


  • "rs2072743","X","43484465","TT"=CC Orientation minus
[PMID 19455600] a haplotype consisting of rs3027400(G) and rs2072743(C) associated with increased incidence of migraine without aura among a sample of 528 migraine patients (308 without aura, 220 with aura) and 528 sex-matched migraine-free controls
[PMID 20691428] A cis-Phase Interaction Study of Genetic Variants Within the MAOA Gene in Major Depressive Disorder
http://www.snpedia.com/index.php/Rs2072743


  • rs1799971 6 154402490 AG
Rs1799971(A;A) 0 normal
Rs1799971(A;G) 2.5 stronger cravings for alcohol. if alcoholic, naltrexone treatment 2x more successful
Rs1799971(G;G) 2.6 more pain
http://www.snpedia.com/index.php/Rs1799971(A;G)


  • rs1799971 6 154402490 AG
Rs1799971(A;A) 0 normal
Rs1799971(A;G) 2.5 stronger cravings for alcohol. if alcoholic, naltrexone treatment 2x more successful
Rs1799971(G;G) 2.6 more pain
http://www.snpedia.com/index.php/Rs1799971(A;G)


  • "rs2167079","11","47226831","CC"=TT Orientation minus
http://biochem.stanford.edu/biochem230/nominations/FALL2008NOMINATIONS/autism%20genetics.pdf
For chromosome 11, the maximum occurs in 11p13 (Z lr = 3.33 at rs2421826)
Nature Genetics - 39, 319 - 328 (2007) Published online: 18 February 2007; | doi:10.1038/ng1985
Mapping autism risk loci using genetic linkage and chromosomal rearrangements
http://www.nature.com/ng/journal/v39/n3/fig_tab/ng1985_F3.html
per the spittoon, the minor allele of this SNP (T) was associated with increased HDL cholesterol
http://www.snpedia.com/index.php/Rs2167079


TPH2 Chromosome 12[edit]

72332715
72332153 GB37.2
"rs11178997","12","70618420","TT"
http://archpsyc.ama-assn.org/cgi/content/full/63/10/1103/YOA50450T4
http://www.snpedia.com/index.php/Rs11178997
72331923 GB37.2
"rs4570625","12","70618190","GG"=1.9 Anxiety,TT-MP
72335794 GB37.2
72335855 GB37.2
72336769 GB37.2
"rs4565946","12","70623036","TT"-Risk Allele is CC,TT-MP
72338628
72342284
72348698
"rs1843809","12","70634965","TT"
72350026
72350790
72352543
72355179
72366186
"rs7963720","12","70652453","TT"
72366306
"rs17110563","12","70652573","CC
  • "rs17110563","12","70652573","CC" Most Common
rs17110563, also known as Pro206Ser, is a SNP in the TPH2 gene. The minor allele of this SNP yielded an odds :ratio of 4.8 (CI:1.6-14.8) for increased risk for bipolar disorder in a study of 883 Russian patients.[PMID 17905754]
http://www.snpedia.com/index.php/Rs17110563
72372833
72372862
"rs7305115","12","70659129","GG"
72385500
"rs10506645","12","70671767","CC"
72388374
72396996
"rs4760820","12","70683263","GC"
72400851
72404378
rs1473473 12 70690645 TT
72405059
"rs1487276","12","70691326","CC"
72407997
"rs17110690","12","70694264","GG"
72410292
"rs1487275","12","70696559","AA"
72412572
rs1487275 12 70696559 AA
72412494
"rs1386483","12","70698761","CC"
72412220
72414563
"rs10879357","12","70700830","GG"
72416235
72425324


ADHD[edit]


  • "rs3027415","X","43499385","TT"
exploration of 19 serotoninergic candidate genes in adults and children with attention-deficit/hyperactivity disorder identifies association for 5HT2A, DDC and MAOB. C allele associated with adult ADHD inattentive type.
http://www.snpedia.com/index.php/Rs3027415



SLC6A2 is a transporter gene for the neurotransmitter noradrenaline which is also known as norepinephrine.It is one of the genes being studied for association to ADHD.[edit]

55690425
"rs2242446","16","54247926","TC"
55695106
55696756
rs36029 16 54254257 AG
55698027
rs1532701 16 54255528 AG
55702549
"rs734980","16","54260050","AA"
55704042
"rs187715","16","54261543","TT"
55713088
"rs36020","16","54270589","CC"
55713088
"rs36020","16","54270589","CC"
55716550
"rs3785152","16","54274051","CC"
55716840
"rs40147","16","54274341","AG"
55718818
55720458
55722390
55726058
55728406
55729836
"rs3785157","16","54287337","CC"
55722390
55729836
"rs3785157","16","54287337","CC"
55730124
"rs5568","16","54287625","CC"
55731575
rs1566652 16 54289076 TT
55731835
"rs5569","16","54289336","GG"
55731917
55731946
55733559