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While not diagnosed in my family, this has been a problem. They claim you can never have alcohol if you have this problem. I was an episodic alcoholic in my 20s and stopped drinking for 21 years. Since entering my 50s, I have drank only moderately, though even that is now restricted because it makes me sick due to my Type II Diabetes. I have not had three drinks in one month, much less one day, for about five years. Moderate drinkers have less than 12 drinks a week and no more than three in a day.

  • Rs279871-RA=AA
  • Rs279845-RA=TT
  • Rs279836-RA=AA
  • Rs1799971(G) allele appear to have stronger cravings
  • Rs1076560(A) alleles were 1.3 fold more associated with Alcoholism than the rs1076560(C) alleles.
  • Rs27072(C;C)2x risk of severe alcohol withdrawal
  • Rs27048(C;C)2x risk of severe alcohol withdrawal
  • Rs1042173(T;T)among alcoholics, likely to be heavier drinkers
  • Linked to heavy alcohol consumption in a study of 417 Spanish adults-
  • Rs2232165(T)increased risk for heavy alcohol consumption
rs2232165 3 173648838 GG=CC

Associations and interactions between SNPs in the alcohol metabolizing genes and alcoholism phenotypes in European Americans[edit]


The ALDH1A3 Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The enzyme encoded by this gene uses retinal as a substrate, either in a free or cellular retinol-binding protein form.[PMID 16004729]

Several SNPs in ALDH1A3 A number of ALDH genes are upregulated as a part of the oxidative stress response and inexplicably overexpressed in various tumours, leading to problems during cancer chemotherapy. Mutations in ALDH genes cause inborn errors of metabolism--such as the Sjögren-Larsson syndrome, type II hyperprolinaemia and gamma-hydroxybutyric aciduria--and are likely to contribute to several complex diseases, including cancer and Alzheimer's disease. The ALDH gene products appear to be multifunctional proteins, possessing both catalytic and non-catalytic properties.

99256385 rs7182884 A or C CC[edit]

dbSNP Orientation: Plus dbSNP Genotype: CC


Alternative Population Sources[edit]
? (A;A) (A;C) (C;C)

99256385 rs7182884 A or C CC[edit]

dbSNP Orientation: Plus dbSNP Genotype: CC

Alternative Population Sources[edit]

99263793 rs4246328 A or G AG[edit]

dbSNP Orientation: Plus dbSNP Genotype: AG


Alternative Population Sources[edit]
? (A;A) (A;G) (G;G)

99265497 rs11854028 G or T GT[edit]

dbSNP Orientation: Plus dbSNP Genotype: GT


Alternative Population Sources[edit]
? (A;A) (A;G) (G;G)