Study: Archaic Hominid Introgression in Africa Contributes to Functional Salivary MUC7 Genetic Variation: "Here, we found that PTS-repeat copy number variation has evolved recurrently in the human lineage, thereby generating multiple haplotypic backgrounds carrying five or six PTS-repeat copy number alleles. Contrary to previous studies, we found no associations between the copy number of PTS-repeats and protection against asthma. Instead, we revealed a significant association of MUC7 haplotypic variation with the composition of the oral microbiome. Furthermore, based on in-depth simulations, we conclude that a divergent MUC7 haplotype likely originated in an unknown African hominin population and introgressed into ancestors of modern Africans."
The Guardian: "The secret about human evolution found in spit"
| GWAS snp
|
| PMID
|
[PMID 21529783 ]
|
| Trait
|
|
| Title
|
A Quantitative-Trait Genome-Wide Association Study of Alcoholism Risk in the Community: Findings and Implications.
|
| Risk Allele
|
G
|
| P-val
|
0.000005
|
| Odds Ratio
|
0.1000 [NR] unit increase
|
]
