rs1801320
| Orientation | plus |
| Stabilized | plus |
| Make rs1801320(C;C) |
| Make rs1801320(C;G) |
| Make rs1801320(G;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 15 |
| Position | 40695330 |
| Gene | RAD51, RAD51-AS1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1801320 |
| dbSNP (classic) | rs1801320 |
| ClinGen | rs1801320 |
| ebi | rs1801320 |
| HLI | rs1801320 |
| Exac | rs1801320 |
| Gnomad | rs1801320 |
| Varsome | rs1801320 |
| LitVar | rs1801320 |
| Map | rs1801320 |
| PheGenI | rs1801320 |
| Biobank | rs1801320 |
| 1000 genomes | rs1801320 |
| hgdp | rs1801320 |
| ensembl | rs1801320 |
| geneview | rs1801320 |
| scholar | rs1801320 |
| rs1801320 | |
| pharmgkb | rs1801320 |
| gwascentral | rs1801320 |
| openSNP | rs1801320 |
| 23andMe | rs1801320 |
| SNPshot | rs1801320 |
| SNPdbe | rs1801320 |
| MSV3d | rs1801320 |
| GWAS Ctlg | rs1801320 |
| GMAF | 0.1304 |
| Max Magnitude | 0 |
| ? | (C;C) (C;G) (G;G) | 28 |
|---|---|---|
|
| ||
rs1801320, also known as 135G>C, is a SNP in the 5'-untranslated region (UTR) of the RAD51 gene.
A meta-analysis of 12 studies involving 7,065 cases and 6,981 controls found no evidence for a significant association between rs1801320 and risk for breast cancer in non-BRCA1/BRCA1 carriers, contrary to a previous report.[PMID 20461453]
[PMID 17999359
] rs1801320 in the CIMBA study so perhaps breast cancer related
[PMID 21725594] Combined effect of polymorphisms in Rad51 and Xrcc3 on breast cancer risk and chromosomal radiosensitivity
[PMID 17889711] RAD51 135G>C polymorphism and risk of familial breast cancer in a South American population.
[PMID 19276285] Associations between single nucleotide polymorphisms in double-stranded DNA repair pathway genes and familial breast cancer.
[PMID 19536092] Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array.
[PMID 19584272] Modification of ovarian cancer risk by BRCA1/2-interacting genes in a multicenter cohort of BRCA1/2 mutation carriers.
[PMID 20386703] Association between DNA damage response and repair genes and risk of invasive serous ovarian cancer.
[PMID 21104022] Polymorphisms in RAD51, XRCC2 and XRCC3 genes of the homologous recombination repair in colorectal cancer--a case control study.
[PMID 24568492] Equivocal Association of RAD51 Polymorphisms with Risk of Esophageal Squamous Cell Carcinoma in a Chinese Population
[PMID 24930116] Association of polymorphisms in the 5' untranslated region of RAD51 gene with risk of endometrial cancer in the Polish population
[PMID 26339569] Polymorphisms of Homologous Recombination RAD51, RAD51B, XRCC2, and XRCC3 Genes and the Risk of Prostate Cancer
[PMID 26974709] Polymorphisms in double strand break repair related genes influence radiosensitivity phenotype in lymphocytes from healthy individuals.
| ClinVar | |
|---|---|
| Risk | rs1801320(C;C) |
| Alt | rs1801320(C;C) |
| Reference | rs1801320(G;G) |
| Significance | Other |
| Disease | Breast cancer |
| Variation | info |
| Gene | RAD51-AS1 RAD51 |
| CLNDBN | Breast cancer, susceptibility to, in BRCA1 and BRCA2 carriers |
| Reversed | 0 |
| HGVS | NC_000015.9:g.40987528G>C |
| CLNSRC | OMIM Allelic Variant |
| CLNACC | RCV000014008.2, |
[PMID 29111564] Relationship between XPD, RAD51, and APEX1 DNA repair genotypes and prostate cancer risk in the male population of Rio de Janeiro, Brazil.
[PMID 30033552] Clinicopathological significance of SNPs in RAD51 and XRCC3 in oral and oropharyngeal carcinomas.
[PMID 31905201] Rad51 paralogs and the risk of unselected breast cancer: A case-control study.
