Two APOL1 alleles have been shown to be strongly associated with focal segmental glomerulosclerosis and end-stage renal disease in African Americans, Hispanic Americans and in individuals of African descent. The APOL1 G1 allele, defined by the derived alleles of coding SNPs rs73885319 (p.S342G) and rs60910145 (p.I384M), and the APOL1 G2 allele, defined by the derived allele for indel rs71785313 (p.NYK388K). 10.1126/science.1193032 and 10.1007/s00439-010-0861-0.
Customers of 23andMe can use the presence of the A allele for coding SNP rs2239785 (p.E150K) or the presence of the G allele for coding SNP rs136175 (p.M228I) or coding SNP rs136176 (p.R255K) to exclude the presence of alleles G1 and G2, although absence of these alleles does not imply presence of either G1 or G2. Furthermore, presence of the T allele for SNP rs4419330 excludes the presence of allele G2 and presence of the C allele for SNP rs4419330 excludes the presence of allele G1.