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Age related macular degeneration

From SNPedia
(Redirected from ARMD)

A scene as it might appear to a person with ARMD

Age related macular degeneration (ARMD) is the leading cause of blindness for people over 50. An informative overview about eye health, focusing on glaucoma and macular degeneration, is online here on the nonprofit BrightFocus Foundation website.

ARMD is a complex disease with associated mutations in many genes. A 2016 study analyzing 16,144 patients and 17,832 controls identified 52 independently associated common and rare variants distributed across 34 genes, and concluded that the hunt for additional genes will probably be fruitful but will require extremely large sample sizes.[PMID 26691988]

omim summarizes current research

Many different SNPs can trigger the disease [PMID 11673412], including:

  • rs3775291 can reduce the risk of having dry ARMD

Macular Degeneration


Hageman [PMID 15870199]

Klein [PMID 18682806]

Li [PMID 16936733]

Maller [PMID 16936732]

Tuo [PMID 16754848]

Chen [PMID 18048322]

Ng [PMID 18421087]

Francis [PMID 18682806]

Gold [PMID 16518403]

Maller [PMID 16936732]

Gold [PMID 16518403]

Maller [PMID 16936732]

Maller [PMID 16936732]

Francis [PMID 18682806]

Lin [PMID 19026638]

Tuo [PMID 16754848]

HTRA1

Francis [PMID 18682806]

Lin [PMID 19026638]