|(A;A)||2.2||0.44x decreased risk for dry age related macular degeneration|
|(A;G)||2.1||0.71x decreased risk for dry age related macular degeneration|
|(G;G)||2||common but higher risk of age related macular degeneration|
rs3775291 has been associated with one form of age related macular degeneration (ARMD), specifically, the form known as "dry" ARMD, also known as geographic atrophy. A study of 3 case-control groups of Americans of European descent, comprising about 900 ARMD patients in total, indicated that having one rs3775291(A) allele reduces the odds of having dry ARMD about 30%, and being a rs3775291(A;A) homozygote cuts your odds by more than half. Specifically, the odds ratio of having dry ARMD with one minor allele is 0.712 (CI: 0.50-1.0), and for two minor alleles, 0.437 ( CI: 0.227-0.839). This was highly significant for the pooled populations (p = 1.24x10eâ€“7) and also in each population independently(p = 0.002-0.005).[PMID 18753640]
Results of three independent samples did not confirm previously reported association of rs3775291 with AMD, individually or combined.[PMID 19628747]
[PMID 19741468] Impact of Polymorphisms of TLR4/CD14 and TLR3 on Acute Rejection in Kidney Transplantation
[PMID 19475618] TLR3 gene polymorphisms and liver disease manifestations in chronic hepatitis C
[PMID 21239167] TLR-3 polymorphism is an independent prognostic marker for stage II colorectal cancer
[PMID 21712495] Toll-like receptor 3 C1234T may protect against geographic atrophy through decreased dsRNA binding capacity
[PMID 22174453] A Common Polymorphism in TLR3 Confers Natural Resistance to HIV-1 Infection
[PMID 22205660] Single nucleotide polymorphisms in the Toll-like receptor 3 and CD44 genes are associated with persistence of vaccine-induced immunity to the serogroup C meningococcal conjugate vaccine
[PMID 15726497] Gene-environment interaction effects on the development of immune responses in the 1st year of life.
[PMID 18385087] Toll-like receptor polymorphisms and age-related macular degeneration.
[PMID 18598732] Vaccine immunogenetics: bedside to bench to population.
[PMID 18847302] Personalized vaccines: the emerging field of vaccinomics.
[PMID 19016379] Association of toll-like receptor 3 gene polymorphism with subacute sclerosing panencephalitis.
[PMID 19026761] Molecular pathology of age-related macular degeneration.
[PMID 19259132] Multilocus analysis of age-related macular degeneration.
[PMID 19505919] Toll-like receptor signaling pathway variants and prostate cancer mortality.
[PMID 21079408] Toll-like receptor 3 polymorphism rs3775291 is not associated with choroidal neovascularization or polypoidal choroidal vasculopathy in Chinese subjects.
[PMID 21216866] A functional Toll-like receptor 3 gene (TLR3) may be a risk factor for tick-borne encephalitis virus (TBEV) infection.
[PMID 21609242] Age-related macular degeneration-susceptibility single nucleotide polymorphisms in a han chinese control population.
[PMID 21872627] Association of polymorphisms in TLR genes and in genes of the Toll-like receptor signaling pathway with cancer risk.
[PMID 22552940] Polymorphisms in Toll-like receptor 3 confer natural resistance to human herpes simplex virus type 2 infection
|qualified_impact||Insufficiently evaluated pharmacogenetic|
[PMID 23576520] Genetic Polymorphisms in Host Innate Immune Sensor Genes and the Risk of Nasopharyngeal Carcinoma in North Africa
[PMID 23962581] Association betweenTLR3 rs3775291 and resistance to HIV among highly exposed Caucasian intravenous drug users
[PMID 24028589] TLR2, TLR3, TLR4 and CD14 gene polymorphisms associated with oral lichen planus risk
[PMID 23466493] Association of common single-nucleotide polymorphisms in innate immune genes with differences in TLR-induced cytokine production in neonates
[PMID 24064706] Polymorphisms within Toll-like receptors are associated with systemic lupus erythematosus in a cohort of Danish females
[PMID 24621100] A Polymorphism in Melanoma Differentiation-associated Gene 5 May Be a Risk Factor for Enterovirus 71 Infection
|Disease||Human immunodeficiency virus type 1|
|CLNDBN||Human immunodeficiency virus type 1, susceptibility to|
|CLNSRC||OMIM Allelic Variant UniProtKB (protein)|
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[PMID 25304972] A non-synonymous single-nucleotide polymorphism in the gene encoding Toll-like Receptor 3 (TLR3) is associated with sero-negative Rheumatoid Arthritis (RA) in a Danish population
[PMID 25720507] A toll-like receptor 3 single nucleotide polymorphism in Japanese patients with sarcoidosis