Ibuprofen

From SNPedia

Ibuprofen belongs to the groups of nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs are generally indicated for the symptomatic relief of rheumatoid arthritis and other acute or chronic conditions where pain and inflammation are present. Ibuprofen and aspirin are among the NSAIDs that have become accepted as relatively safe and are available over-the-counter without prescription. A recent study concludes that some NSAIDs (most notably Ibuprofen) may protect against Alzheimer's disease. Compared with no NSAID use, the adjusted odds ratios for AD among ibuprofen users decreased from 1.03 (1.00–1.06) to 0.56 (0.42–0.75) for >5 years of use (0.68–0.85).

Ibuprofen is believed to work through inhibition of cyclooxygenase (COX, PTGS2), thus inhibiting prostaglandin synthesis.