Ibuprofen is an over-the-counter nonsteroidal anti-inflammatory drug. According to Wikipedia, NSAIDs (Non-steroidal anti-inflammatory drugs) are used to relieve the pain and inflammation of rheumatoid arthritis and other acute or chronic conditions. Ibuprofen and aspirin are among the NSAIDs that have become accepted as relatively safe and are available without prescription.
A recent study concludes that some NSAIDs (most notably ibuprofen) may protect against Alzheimer's disease (AD). Compared with no NSAID use, the adjusted odds ratios for AD among ibuprofen users decreased from 1.03 (1.00-1.06) to 0.56 (0.42-0.75) for >5 years of use (0.68-0.85).
- [PMID 19422321] Genetically based impairment in CYP2C8- and CYP2C9-dependent NSAID metabolism as a risk factor for gastrointestinal bleeding: is a combination of pharmacogenomics and metabolomics required to improve personalized medicine?
- [PMID 18216720] PharmGKB summary: very important pharmacogene information for cytochrome P450, family 2, subfamily C, polypeptide 8