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rs10509681

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 2
(T;T) 0 common on affy axiom data
Make rs10509681(C;T)
ReferenceGRCh38 38.1/142
Chromosome10
Position95038992
GeneCYP2C8
is asnp
is mentioned by
dbSNPrs10509681
ebirs10509681
HLIrs10509681
Exacrs10509681
Varsomers10509681
Maprs10509681
PheGenIrs10509681
hapmaprs10509681
1000 genomesrs10509681
hgdprs10509681
ensemblrs10509681
gopubmedrs10509681
geneviewrs10509681
scholarrs10509681
googlers10509681
pharmgkbrs10509681
gwascentralrs10509681
openSNPrs10509681
23andMers10509681
23andMe allrs10509681
SNP Nexus

SNPshotrs10509681
SNPdbers10509681
MSV3drs10509681
GWAS Ctlgrs10509681
GMAF0.06474
Max Magnitude2
? (C;C) (C;T) (T;T) 28
CYP2C8 SNP, defining the CYP2C8*3 allele (along with rs11572080).

Individuals carrying this SNP may show increased risk of developing acute gastrointestinal bleeding during the use of NSAIDs that are CYP2C8 or CYP2C9 substrates, such as aceclofenac, celecoxib, diclofenac, ibuprofen, indomethazine, lornoxicam, meloxicam, naproxen, piroxicam, tenoxicam and valdecoxib.[PMID 19422321]







[PMID 18769365OA-icon.png] Role of cytochrome P450 2C8 and 2J2 genotypes in calcineurin inhibitor-induced chronic kidney disease.


[PMID 19761371OA-icon.png] Cytochrome P450 2C8 pharmacogenetics: a review of clinical studies.


[PMID 20389299OA-icon.png] Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism.


[PMID 20808793OA-icon.png] Are cytochrome P450 CYP2C8 and CYP2C9 polymorphisms associated with ibuprofen response in very preterm infants?


[PMID 21324488] Single nucleotide polymorphisms in tobacco metabolism and DNA repair genes and prognosis in resected non-small-cell lung cancer.


GET Evidence
CYP2C8-K399R
aa_change Lys399Arg
aa_change_short K399R
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.0866332
summary Impaired metabolism of paclitaxel in vitro, lower plasma concentration of repaglinide and rosiglitazone.



[PMID 23267857] CYP2C19*17 Gain-of-Function Polymorphism Is Associated With Peptic Ulcer Disease


[PMID 23413280OA-icon.png] CYP2C8*3 increases risk of neuropathy in breast cancer patients treated with paclitaxel


[PMID 23420707OA-icon.png] Analysis of the Functional Polymorphism in the Cytochrome P450 CYP2C8 Gene rs11572080 with Regard to Colorectal Cancer Risk


[PMID 23130019OA-icon.png] Frequencies of 23 functionally significant variant alleles related with metabolism of antineoplastic drugs in the chilean population: comparison with caucasian and asian populations.


[PMID 23426382] The role of genetic variants in CYP2C8, LPIN1, PPARGC1A and PPARgamma on the trough steady-state plasma concentrations of rosiglitazone and on glycosylated haemoglobin A1c in type 2 diabetes.