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MAOA

From SNPedia

is agene
is mentioned by
Full namemonoamine oxidase A
RelatedMAOB
EntrezGene4128
PheGenI4128
VariationViewer4128
ClinVarMAOA
GeneCardsMAOA
dbSNP4128
SADR4128
HugeNav4128
wikipediaoxidase A Monoamine oxidase A
googleMAOA
gopubmedMAOA
EVSMAOA
HEFalMpMAOA
MyGene2MAOA
23andMeMAOA
UniProtP21397
EnsemblENSG00000189221
OMIM309850
# SNPs19
 Max MagnitudeChromosome positionSummary
rs113707043,744,144
rs146510743,678,769
rs207274343,740,274
rs223518643,736,181
rs228372543,700,729
rs302740043,733,516
rs302740743,745,594
rs3027409043,747,786
rs587777457043,731,695
rs590688343,667,695
rs590695743,688,062
rs595321043,654,798
rs6323343,731,789Monoamine oxidase A activity
rs660925743,753,461
rs72554632543,731,784
rs79606531143,731,344
rs796065312043,683,572
rs909525243,693,955Best proxy for Warrior Gene repeats.
rs97960643,741,895

The MAOA monoamine-oxidase A gene, encodes an enzyme partially responsible for the metabolism of several neurotransmitters such as dopamine and serotonin. The monoamine oxidase family of enzymes, which metabolize monoamines (neurotransmitters and neuromodulators consisting of a single amine), includes MAOA and MAOB.

Although not a SNP per se, the variation that has been most studied consists of a 30 base-pair variable number tandem repeat (VNTR) located in the promoter region of the gene. Alleles with 3.5 and 4 repeats are 2-10 times more productive than the allele with 3 repeats. Several studies have shown an association between the 3-repeat allele and neuropsychiatric conditions such as alcoholism, antisocial personality, impulsivity, and poor reaction to stress, leading some popular media to label this allele the "warrior gene".

blog affects aggression after provocation pnas

Brunner syndrome: a recessive X-linked disorder characterized by impulsive aggressiveness and mild mental retardation resulting from MAOA deficiency OMIM; dbSNP reports a probably pathogenic allele detected by SNP rs72554632 C/T CAT->TAG QLN->STOP(AMBER), the same SNP associated with Brunner syndrome.