Have questions? Visit https://www.reddit.com/r/SNPedia

MEIS1

From SNPedia

is agene
is mentioned by
Full nameMeis homeobox 1
EntrezGene4211
PheGenI4211
VariationViewer4211
ClinVarMEIS1
GeneCardsMEIS1
dbSNP4211
SADR4211
HugeNav4211
wikipediaMEIS1
googleMEIS1
gopubmedMEIS1
EVSMEIS1
HEFalMpMEIS1
MyGene2MEIS1
23andMeMEIS1
UniProtO00470
EnsemblENSG00000143995
OMIM601739
# SNPs10
 Max MagnitudeChromosome positionSummary
rs1086535566,537,865
rs1167835466,532,947
rs1189711966,544,868
rs12469063266,537,176
rs219295466,550,389
rs2300478266,554,321
rs389158566,529,844
rs454442366,522,885
rs6710341266,531,290
rs978953566,538,446

The MEIS1 gene is most likely important in development, but its functions remain unclear. Several SNPs in the MEIS1 gene, and in particular one haplotype, have been associated with increased risk for restless legs syndrome. [PMID 17637780]

These SNPs and haplotype are:

The association from this region that gives the highest association to restless legs syndrome is the haplotype consisting of the rs6710341(A) and rs12469063(G) alleles. This haplotype gives rise to an odds ratio of 2.75 (CI: 2.23-3.41). [PMID 17637780]