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NOD2

From SNPedia

is agene
is mentioned by
Full namenucleotide-binding oligomerization domain containing 2
EntrezGene64127
PheGenI64127
VariationViewer64127
ClinVarNOD2
GeneCardsNOD2
dbSNP64127
SADR64127
HugeNav64127
wikipediaNOD2
googleNOD2
gopubmedNOD2
EVSNOD2
HEFalMpNOD2
MyGene2NOD2
23andMeNOD2
UniProtQ9HC29
EnsemblENSG00000167207
OMIM605956
# SNPs25
 Max MagnitudeChromosome positionSummary
rs10489543150,711,203
rs104895438050,711,745
rs10489544450,712,288
rs104895460050,711,316
rs104895461050,710,912
rs104895462050,710,911
rs104895472050,711,398
rs104895476050,711,057
rs104895477050,711,058
rs107786150,725,636
rs17221417250,705,671
rs1731326550,713,793
rs206684250,710,713
rs2066843250,711,288
rs2066844450,712,015
rs2066845450,722,629
rs2066847450,729,867
rs206708550,699,948
rs2076756050,722,970
rs313549950,732,216
rs313550050,732,975
rs574327750,712,018
rs5743289150,722,863
rs5743293050,729,870
rs805734150,704,069


[PMID 17568627] NOD2 3020insC (either rs2066847 or rs5743293) is the most common and highest risk variant in Crohn's disease.

[PMID 18371140] Carriers of any of several NOD2 variant SNPs do not respond well to treatment of perianal fistulating Crohn's disease by the antibiotics ciprofloxacin or metronidazole, whereas carriers of wild-type NOD2 genes have at least some chance (1 in 3) of responding well.

[PMID 17724347] NOD2/CARD15 SNP variants are associated with an increased risk of relapse and death for patients with acute leukemia after hematopoietic stem-cell transplantation (HSCT) with unrelated donors as compared with wild-type pairs. NOD2/CARD15 genotyping before transplantation may contribute to prognosis and influence clinical management.

[PMID 18756601] No association was found for NOD2/CARD15 SNPs (R702W, G908R) in Chinese patients with inflammatory bowel disease.

The 23andMe blog 23andme blog reports that the C allele at rs9302752, a SNP in the NOD2 gene, is associated with greater susceptibility to leprosy in Asians (odds ratio 1.59).

[PMID 11385576] These observations suggest that the NOD2 gene product confers susceptibility to Crohn's disease by altering the recognition of these components and/or by over-activating NF-kB in monocytes, thus documenting a molecular model for the pathogenic mechanism of Crohn's disease that can now be further investigated.