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Nicotine

From SNPedia

Nicotine is a highly addictive and potent stimulant most commonly acquired through smoking cigarettes. Wikipedia

The primary therapeutic use of nicotine is in treating nicotine dependence in order to eliminate smoking and thereby its damaging health consequences. Nicotine replacement therapy (NRT) is a medically-approved way to take nicotine by means other than tobacco.Wikipedia

A variant in the COMT gene, rs4680, has been observed in some studies to be correlated with smoking cessation success via nicotine replacement therapy.

PGx Table for Nicotine (Nicoderm)
Genotype/Genoset Diplotype Gene Drug Use/Category/Class Medical Field Summary Descriptive Sentence
rs4680(A;A) Met/Met COMT Smoking Cessation Psychiatry Normal Response Expected You have the COMT genotype with a higher likelihood of quitting smoking via nicotine replacement therapy.
rs4680(A;G) Met/Val COMT Smoking Cessation Psychiatry Consider Alternatives You have a COMT genotype with a somewhat lower likelihood of quitting smoking via nicotine replacement therapy.
rs4680(G;G) Val/Val COMT Smoking Cessation Psychiatry Consider Alternatives You have a COMT genotype with a somewhat lower likelihood of quitting smoking via nicotine replacement therapy.