COMT

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is agene
is mentioned by
Full namecatechol-O-methyltransferase
EntrezGene1312
PheGenI1312
VariationViewer1312
ClinVarCOMT
dbSNP1312
SADR1312
HugeNav1312
wikipediaCOMT
googleCOMT
gopubmedCOMT
EVSCOMT
HEFalMpCOMT
23andMeCOMT
UniProtP21964
EnsemblENSG00000093010
OMIM116790
EVSCOMT
# SNPs27
 Max MagnitudeChromosome positionSummary
Rs16559919,969,258
Rs16565619,961,340
Rs16568819,963,748
Rs16572219,961,490
Rs16577419,965,038
Rs1784930819,963,748
Rs202091719,941,361
Rs207550719,940,569
Rs209760319,940,569
Rs223939319,962,905
Rs308786919,953,984
Rs463319,962,712
Rs464631219,960,814
Rs464631619,964,609
Rs468019,963,748warrior vs worrier
Rs481819,963,684
Rs599388219,950,010
Rs626719,962,740
Rs626919,962,429
Rs73786519,942,598
Rs73786619,942,586
Rs74060219,962,745
Rs74060319,957,654
Rs76922419,964,281
Rs819248819,963,714
Rs933237719,968,169
Rs93327119,943,884

Variations in this gene control dopamine levels. This can be used to pick appropriate dosages of ADHD medications [1].

COMT met158 allele associated with OCD in men [PMID 17264842]

[PMID 18698234] 4 SNPs affecting COMT activity were used to define low and high activity haplotypes. These SNPs are: rs6269, rs4633, rs4818, and rs4680. The mean levodopa dose increased in correspondence with the haplotype activity (low < medium < high). Doses prescribed for G-C-G-G (high activity) haplotype carriers (mean 604.2+/-261.9 mg) were significantly higher than those for the noncarriers (mean 512.2+/-133.5 mg, p<0.05).