COMT

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is agene
is mentioned by
Full namecatechol-O-methyltransferase
EntrezGene1312
PheGenI1312
VariationViewer1312
dbSNP1312
SADR1312
HugeNav1312
wikipediaCOMT
googleCOMT
gopubmedCOMT
EVSCOMT
HEFalMpCOMT
23andMeCOMT
UniProtP21964
EnsemblENSG00000093010
OMIM116790
EVSCOMT
# SNPs26
  Max Magnitude Chromosome position Summary
Rs165599 1.5 19,956,781
Rs165688 0 19,951,271
Rs165722 19,949,013
Rs165774 19,952,561
Rs17849308 19,951,271
Rs2020917 19,928,884
Rs2075507 19,928,092
Rs2097603 19,928,092
Rs2239393 19,950,428
Rs3087869 19,941,507
Rs4633 19,950,235
Rs4646312 19,948,337
Rs4646316 19,952,132
Rs4680 2.5 19,951,271 warrior vs worrier
Rs4818 19,951,207
Rs5993882 19,937,533
Rs6267 0 19,950,263
Rs6269 19,949,952
Rs737865 19,930,121
Rs737866 19,930,109
Rs740602 0 19,950,268
Rs740603 19,945,177
Rs769224 19,951,804
Rs8192488 0 19,951,237
Rs9332377 0 19,955,692
Rs933271 19,931,407

Variations in this gene control dopamine levels. This can be used to pick appropriate dosages of ADHD medications [1].

COMT met158 allele associated with OCD in men [PMID 17264842]

[PMID 18698234] 4 SNPs affecting COMT activity were used to define low and high activity haplotypes. These SNPs are: rs6269, rs4633, rs4818, and rs4680. The mean levodopa dose increased in correspondence with the haplotype activity (low < medium < high). Doses prescribed for G-C-G-G (high activity) haplotype carriers (mean 604.2+/-261.9 mg) were significantly higher than those for the noncarriers (mean 512.2+/-133.5 mg, p<0.05).