COMT
From SNPedia
| is a | gene |
| is | mentioned by |
| Full name | catechol-O-methyltransferase |
| EntrezGene | 1312 |
| PheGenI | 1312 |
| VariationViewer | 1312 |
| dbSNP | 1312 |
| SADR | 1312 |
| HugeNav | 1312 |
| wikipedia | COMT |
| COMT | |
| gopubmed | COMT |
| EVS | COMT |
| HEFalMp | COMT |
| 23andMe | COMT |
| UniProt | P21964 |
| Ensembl | ENSG00000093010 |
| OMIM | 116790 |
| EVS | COMT |
| # SNPs | 23 |
| Max Magnitude | Chromosome position | Summary | |
|---|---|---|---|
| Rs165599 | 1.5 | 19,956,781 | |
| Rs165688 | 0 | 19,951,271 | |
| Rs165722 | 19,949,013 | ||
| Rs165774 | 19,952,561 | ||
| Rs17849308 | 19,951,271 | ||
| Rs2020917 | 19,928,884 | ||
| Rs2075507 | 19,928,092 | ||
| Rs2097603 | 19,928,092 | ||
| Rs2239393 | 19,950,428 | ||
| Rs4633 | 19,950,235 | ||
| Rs4646316 | 19,952,132 | ||
| Rs4680 | 2.5 | 19,951,271 | warrior vs worrier |
| Rs4818 | 19,951,207 | ||
| Rs6267 | 0 | 19,950,263 | |
| Rs6269 | 19,949,952 | ||
| Rs737865 | 19,930,121 | ||
| Rs737866 | 19,930,109 | ||
| Rs740602 | 0 | 19,950,268 | |
| Rs740603 | 19,945,177 | ||
| Rs769224 | 19,951,804 | ||
| Rs8192488 | 0 | 19,951,237 | |
| Rs9332377 | 0 | 19,955,692 | |
| Rs933271 | 19,931,407 |
Variations in this gene control dopamine levels. This can be used to pick appropriate dosages of ADHD medications [1].
COMT met158 allele associated with OCD in men [PMID 17264842]
[PMID 18698234] 4 SNPs affecting COMT activity were used to define low and high activity haplotypes. These SNPs are: rs6269, rs4633, rs4818, and rs4680. The mean levodopa dose increased in correspondence with the haplotype activity (low < medium < high). Doses prescribed for G-C-G-G (high activity) haplotype carriers (mean 604.2+/-261.9 mg) were significantly higher than those for the noncarriers (mean 512.2+/-133.5 mg, p<0.05).
