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rs1061622

From SNPedia

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ReferenceGRCh38 38.1/141
Chromosome1
Position12192898
GeneTNFRSF1B
is asnp
is mentioned by
dbSNPrs1061622
ebirs1061622
HLIrs1061622
Exacrs1061622
Varsomers1061622
Maprs1061622
PheGenIrs1061622
hapmaprs1061622
1000 genomesrs1061622
hgdprs1061622
ensemblrs1061622
gopubmedrs1061622
geneviewrs1061622
scholarrs1061622
googlers1061622
pharmgkbrs1061622
gwascentralrs1061622
openSNPrs1061622
23andMers1061622
23andMe allrs1061622
SNP Nexus

SNPshotrs1061622
SNPdbers1061622
MSV3drs1061622
GWAS Ctlgrs1061622
GMAF0.197
Max Magnitude
? (G;G) (G;T) (T;T) 28
[PMID 19343543OA-icon.png] Association analysis of TNFRSF1B polymorphisms with type 2 diabetes and its related traits in North India.


[PMID 19421420OA-icon.png] Tumor Necrosis Factor Receptor Superfamily, Member 1B Haplotypes Increase or Decrease the Risk of Inflammatory Bowel Diseases in a New Zealand Caucasian Population



[PMID 19684152] Cigarette smoking, STAT4 and TNFRSF1B polymorphisms, and systemic lupus erythematosus in a Japanese population


[PMID 21995493OA-icon.png] TNFRSF1B +676 T>G polymorphism predicts survival of non-Small cell lung cancer patients treated with chemoradiotherapy

[PMID 15113403OA-icon.png] Current limitations of SNP data from the public domain for studies of complex disorders: a test for ten candidate genes for obesity and osteoporosis.

[PMID 16109524] Preparation and analysis of cSNP chip on hepatocellular carcinoma-related genes.

[PMID 16380915OA-icon.png] Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4.

[PMID 17705862OA-icon.png] Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.

[PMID 18248655] Genetic polymorphisms of tumour necrosis factor receptor superfamily 1A and 1B affect responses to infliximab in Japanese patients with Crohn's disease.

[PMID 18385279] The tumour necrosis factor receptor superfamily member 1b 676T>G polymorphism in relation to response to infliximab and adalimumab treatment and disease severity in rheumatoid arthritis.

[PMID 18466472OA-icon.png] Constructing gene association networks for rheumatoid arthritis using the backward genotype-trait association (BGTA) algorithm.

[PMID 18466513OA-icon.png] Evaluating gene x gene and gene x smoking interaction in rheumatoid arthritis using candidate genes in GAW15.

[PMID 18603647OA-icon.png] Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.

[PMID 18805939OA-icon.png] Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.

[PMID 19401444OA-icon.png] Body iron stores and glucose intolerance in premenopausal women: role of hyperandrogenism, insulin resistance, and genomic variants related to inflammation, oxidative stress, and iron metabolism.

[PMID 20007930OA-icon.png] A functional haplotype in the 3'untranslated region of TNFRSF1B is associated with tuberculosis in two African populations.

[PMID 20018049OA-icon.png] Evaluation of an optimal receiver operating characteristic procedure.

[PMID 20646319OA-icon.png] TNFRSF1B A1466G genotype is predictive of clinical efficacy after treatment with a definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma.

[PMID 20811626OA-icon.png] Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.


GET Evidence
TNFRSF1B-M196R
aa_change Met196Arg
aa_change_short M196R
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.231735
summary Low response to Infliximab.



[PMID 22860894] Genetic polymorphisms of tumour necrosis factor receptor superfamily 1b and fas ligand are associated with clinical efficacy and/or acute severe infusion reactions to infliximab in Crohn's disease


[PMID 23799986] Maternal tumor necrosis factor receptor 2 gene variants associated with pre-eclampsia in Tunisian women


[PMID 22921902OA-icon.png] The methionine 196 arginine polymorphism of the TNF receptor 2 gene (TNFRSF1B) is not associated with worse outcomes in heart failure.


[PMID 23238918] Genome-wide pathway analysis of a genome-wide association study on multiple sclerosis.


[PMID 25010932OA-icon.png] Association of TNF-α, TNFRSF1A and TNFRSF1B Gene Polymorphisms with the Risk of Sporadic Breast Cancer in Northeast Chinese Han Women


[PMID 25850964] Genetic variants within the TNFRSF1B gene and susceptibility to rheumatoid arthritis and response to anti-TNF drugs: a multicenter study


[PMID 26071216] The tumor necrosis factor receptor superfamily member 1B polymorphisms predict response to anti-TNF therapy in patients with autoimmune disease: A meta-analysis