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rs10889353

From SNPedia

Orientationplus
Stabilizedplus
Make rs10889353(A;A)
Make rs10889353(A;C)
Make rs10889353(C;C)
ReferenceGRCh38 38.1/141
Chromosome1
Position62652525
GeneDOCK7
is asnp
is mentioned by
dbSNPrs10889353
ebirs10889353
HLIrs10889353
Exacrs10889353
Varsomers10889353
Maprs10889353
PheGenIrs10889353
hapmaprs10889353
1000 genomesrs10889353
hgdprs10889353
ensemblrs10889353
gopubmedrs10889353
geneviewrs10889353
scholarrs10889353
googlers10889353
pharmgkbrs10889353
gwascentralrs10889353
openSNPrs10889353
23andMers10889353
23andMe allrs10889353
SNP Nexus

SNPshotrs10889353
SNPdbers10889353
MSV3drs10889353
GWAS Ctlgrs10889353
GMAF0.2897
Max Magnitude
? (A;A) (A;C) (C;C) 28
GWAS snp
PMID [PMID 19060911OA-icon.png]
Trait Cholesterol, total
Title Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
Risk Allele C
P-val 4E-12
Odds Ratio 0.08 [NR] SD decrease
GWAS snp
PMID [PMID 19060906OA-icon.png]
Trait Triglycerides
Title Common variants at 30 loci contribute to polygenic dyslipidemia
Risk Allele C
P-val 3E-7
Odds Ratio 0.05 [0.01-0.09] SD decrease




[PMID 19802338OA-icon.png] Genetic loci associated with plasma concentration of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoprotein A1, and Apolipoprotein B among 6382 white women in genome-wide analysis with replication.

[PMID 20160193OA-icon.png] Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples.

[PMID 20502693OA-icon.png] Genetics and beyond--the transcriptome of human monocytes and disease susceptibility.

[PMID 20832063] Exploring genetic determinants of plasma total cholesterol levels and their predictive value in a longitudinal study.

[PMID 21347282OA-icon.png] Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.


GET Evidence
rs10889353
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.335938
summary



GWAS snp
PMID [PMID 20139978]
Trait Triglycerides
Title Genome-wide association study of hematological and biochemical traits in a Japanese population.
Risk Allele C
P-val 2E-9
Odds Ratio .13 [0.085-0.167] unit decrease
GWAS snp
PMID [PMID 19936222OA-icon.png]
Trait Lipid metabolism phenotypes
Title Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.
Risk Allele
P-val 1E-13
Odds Ratio .03 [NR] unit decrease