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rs11225703

From SNPedia

Orientationplus
Stabilizedplus
Make rs11225703(C;C)
Make rs11225703(C;T)
Make rs11225703(T;T)
ReferenceGRCh38 38.1/141
Chromosome11
Position103315230
GeneDYNC2H1
is asnp
is mentioned by
dbSNPrs11225703
ebirs11225703
HLIrs11225703
Exacrs11225703
Varsomers11225703
Maprs11225703
PheGenIrs11225703
hapmaprs11225703
1000 genomesrs11225703
hgdprs11225703
ensemblrs11225703
gopubmedrs11225703
geneviewrs11225703
scholarrs11225703
googlers11225703
pharmgkbrs11225703
gwascentralrs11225703
openSNPrs11225703
23andMers11225703
23andMe allrs11225703
SNP Nexus

SNPshotrs11225703
SNPdbers11225703
MSV3drs11225703
GWAS Ctlgrs11225703
GMAF0.309
Max Magnitude
? (C;C) (C;T) (T;T) 28

This SNP was identified as a "core" SNP helping to define one (of nine total) runs of homozygosity (ROH) potentially associated with increased risk for schizophrenia. Each region consists of at least 100 consecutive SNPs, generally spanning 500KB or more, for which both chromosomes in an individual were homozygous. The overall odds ratio for schizophrenia associated with inheriting 1, 2, or 3 of these 9 ROHs was calculated to be 3.3, 5.4, or 24, respectively, with 95% confidence intervals of (1.9-5.7), (3.7-16.1), and (6.9-83.9), respectively.[PMID 18077426OA-icon.png]

This particular SNP, rs11225703, was deemed to be the core SNP of a region on chromosome 11 with 103 SNPs spanning 458KB from 11:102488778 to 11:102947117 (build 35). Potentially independent of the ROH, the risk allele for this SNP in the orientation as displayed in HapMap v21a is (T).[PMID 18077426OA-icon.png]