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rs11898505

From SNPedia

Orientationplus
Stabilizedplus
Make rs11898505(A;A)
Make rs11898505(A;G)
Make rs11898505(G;G)
ReferenceGRCh38 38.1/141
Chromosome2
Position54457420
GeneSPTBN1
is asnp
is mentioned by
dbSNPrs11898505
ebirs11898505
HLIrs11898505
Exacrs11898505
Varsomers11898505
Maprs11898505
PheGenIrs11898505
hapmaprs11898505
1000 genomesrs11898505
hgdprs11898505
ensemblrs11898505
gopubmedrs11898505
geneviewrs11898505
scholarrs11898505
googlers11898505
pharmgkbrs11898505
gwascentralrs11898505
openSNPrs11898505
23andMers11898505
23andMe allrs11898505
SNP Nexus

SNPshotrs11898505
SNPdbers11898505
MSV3drs11898505
GWAS Ctlgrs11898505
GMAF0.1988
Max Magnitude
? (A;A) (A;G) (G;G) 28
rs11898505 increases susceptibility to Osteoporotic fractures for carriers of the G allele [PMID 18445777]
GWAS snp
PMID [PMID 19079262]
Trait Bone mineral density (spine)
Title New sequence variants associated with bone mineral density
Risk Allele G
P-val 0.000004
Odds Ratio 0.07 [0.04-0.10] SD decrease
GWAS snp
PMID [PMID 19801982OA-icon.png]
Trait Bone mineral density (spine)
Title Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies
Risk Allele A
P-val 2E-8
Odds Ratio 0.07 [0.05-0.09] sd increase



[PMID 19629617OA-icon.png] Replication study of candidate genes/loci associated with osteoporosis based on genome-wide screening.


[PMID 20554715] Analysis of recently identified osteoporosis susceptibility genes in Han Chinese women.


GET Evidence
rs11898505
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.794118
summary



[PMID 22798246] The influence of the genetic and non-genetic factors on bone mineral density and osteoporotic fractures in Chinese women.

GWAS snp
PMID [PMID 24430505OA-icon.png]
Trait Bone properties (heel)
Title Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium.
Risk Allele G
P-val 4E-13
Odds Ratio .06 [0.05-0.08] unit decrease