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From SNPedia

Make rs13281615(A;A)
Make rs13281615(A;G)
Make rs13281615(G;G)
ReferenceGRCh38 38.1/141
is asnp
is mentioned by
1000 genomesrs13281615
23andMe allrs13281615
SNP Nexus

GWAS Ctlgrs13281615
Max Magnitude
? (A;A) (A;G) (G;G) 28
[PMID 18437204OA-icon.png] breast cancer
  • rs13281615 in 8q24 was stronger for ER-positive, PR-positive, and low grade tumors (P = 0.001, 0.011 and 10(-4), respectively) and improvement in survival after diagnosis (per-allele HR = 0.90 (0.83-0.97).

[PMID 19005751] rs13281615 confirmed in 988 sporadic breast cancer cases and 1,016 controls from the West of Ireland to be associated with increased risk (odds ratio 1.17, p(allelic) = 1.8 x 10e-2) for breast cancer

SNP rs13281615
PubMedID [PMID 17529967OA-icon.png]
Condition Breast cancer
Gene Intergenic
Risk Allele T
pValue 5.00E-012
OR 1.08
95% CI 1.05-1.11

[PMID 19656774OA-icon.png] Common variants in LSP1, 2q35 and 8q24 and breast cancer risk for BRCA1 and BRCA2 mutation carriers

[PMID 20145138] Common genetic variants associated with breast cancer and mammographic density measures that predict disease

[PMID 20054709] Birth weight, breast cancer susceptibility loci, and breast cancer risk

[PMID 20699374OA-icon.png] Evaluation of Breast Cancer Susceptibility Loci in Chinese Women

[PMID 21051319OA-icon.png] Risk of Urinary Bladder Cancer is Associated with 8q24 Variant rs9642880[T]: Results from the Los Angeles-Shanghai Case-Control Study

[PMID 21197568] Risk of genome-wide association study newly identified genetic variants for breast cancer in Chinese women of Heilongjiang Province

[PMID 21445572] Genetic polymorphisms and breast cancer risk: evidence from meta-analyses, pooled analyses, and genome-wide association studies

[PMID 21791674OA-icon.png] Interactions Between Genetic Variants and Breast Cancer Risk Factors in the Breast and Prostate Cancer Cohort Consortium

[PMID 21814516OA-icon.png] A Functional Variant at a Prostate Cancer Predisposition Locus at 8q24 Is Associated with PVT1 Expression

[PMID 22087758OA-icon.png] Single nucleotide polymorphisms associated with risk for contralateral breast cancer in the Women's Environment, Cancer and Radiation Epidemiology (WECARE) study

[PMID 22726230OA-icon.png] Interactive effect of genetic susceptibility with height, body mass index, and hormone replacement therapy on the risk of breast cancer

[PMID 17618282OA-icon.png] A common genetic risk factor for colorectal and prostate cancer.

[PMID 17997823OA-icon.png] Clinical correlates of low-risk variants in FGFR2, TNRC9, MAP3K1, LSP1 and 8q24 in a Dutch cohort of incident breast cancer cases.

[PMID 18224312OA-icon.png] Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.

[PMID 18349290] Association of genetic variants at 8q24 with breast cancer risk.

[PMID 18535017OA-icon.png] Pooled analysis of genetic variation at chromosome 8q24 and colorectal neoplasia risk.

[PMID 18577746OA-icon.png] Multiple loci with different cancer specificities within the 8q24 gene desert.

[PMID 18612136OA-icon.png] Discriminatory accuracy from single-nucleotide polymorphisms in models to predict breast cancer risk.

[PMID 18625567] Association of chromosomal locus 8q24 and risk of prostate cancer: a hospital-based study of German patients treated with brachytherapy.

[PMID 18681954OA-icon.png] Breast cancer susceptibility loci and mammographic density.

[PMID 18704501OA-icon.png] Comprehensive resequence analysis of a 136 kb region of human chromosome 8q24 associated with prostate and colon cancers.

[PMID 18708391OA-icon.png] Breast cancer risk polymorphisms and interaction with ionizing radiation among U.S. radiologic technologists.

[PMID 18772892OA-icon.png] Can genes for mammographic density inform cancer aetiology?

[PMID 18785201OA-icon.png] Novel breast cancer risk alleles and endometrial cancer risk.

[PMID 18973230OA-icon.png] Breast cancer susceptibility alleles and ovarian cancer risk in 2 study populations.

[PMID 19088016OA-icon.png] Genetic susceptibility loci for breast cancer by estrogen receptor status.

[PMID 19094228OA-icon.png] The influence of genetic variation in 30 selected genes on the clinical characteristics of early onset breast cancer.

[PMID 19304784OA-icon.png] Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study.

[PMID 19454617OA-icon.png] Genetic variation in the chromosome 17q23 amplicon and breast cancer risk.

[PMID 19528667OA-icon.png] Association of chromosome 8q variants with prostate cancer risk in Caucasian and Hispanic men.

[PMID 19567422OA-icon.png] Risk of estrogen receptor-positive and -negative breast cancer and single-nucleotide polymorphism 2q35-rs13387042.

[PMID 19639606OA-icon.png] Correcting "winner's curse" in odds ratios from genomewide association findings for major complex human diseases.

[PMID 20133699OA-icon.png] Long-range enhancers on 8q24 regulate c-Myc.

[PMID 20146796OA-icon.png] Familial relative risks for breast cancer by pathological subtype: a population-based cohort study.

[PMID 20237344OA-icon.png] Performance of common genetic variants in breast-cancer risk models.

[PMID 20484103OA-icon.png] Genetic and clinical predictors for breast cancer risk assessment and stratification among Chinese women.

[PMID 20605201OA-icon.png] Gene-environment interactions in 7610 women with breast cancer: prospective evidence from the Million Women Study.

[PMID 21596841OA-icon.png] Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium.

[PMID 22045194OA-icon.png] Combined effect of low-penetrant SNPs on breast cancer risk.

[PMID 22160591] A genetic risk predictor for breast cancer using a combination of low-penetrance polymorphisms in a Japanese population.

[PMID 22532573OA-icon.png] The role of genetic breast cancer susceptibility variants as prognostic factors.

GET Evidence
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.460317

[PMID 23565189OA-icon.png] Single Nucleotide Polymorphism 8q24 rs13281615 and Risk of Breast Cancer: Meta-Analysis of More than 100,000 Cases

[PMID 23717390OA-icon.png] Identification of a Breast Cancer Susceptibility Locus at 4q31.22 Using a Genome-Wide Association Study Paradigm

[PMID 24171766OA-icon.png] Common low-penetrance risk variants associated with breast cancer in Polish women

GWAS snp
PMID [PMID 23535729OA-icon.png]
Trait Breast cancer
Title Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
Risk Allele G
P-val 1E-27
Odds Ratio 1.09 [1.07-1.12]

[PMID 22910930OA-icon.png] Genome-Wide Association Studies (GWAS) breast cancer susceptibility loci in Arabs: susceptibility and prognostic implications in Tunisians.

[PMID 22965832] Association of common genetic variants with breast cancer risk and clinicopathological characteristics in a Chinese population.

[PMID 23292077] Association of 8q24 rs13281615A > G polymorphism with breast cancer risk: evidence from 40,762 cases and 50,380 controls.

[PMID 23577780OA-icon.png] Associations between single-nucleotide polymorphisms and epidural ropivacaine consumption in patients undergoing breast cancer surgery.

[PMID 24780616] Frequent Mutation of rs13281615 and Its Association with PVT1 Expression and Cell Proliferation in Breast Cancer

[PMID 24532140] Association of genetic variants at TOX3, 2q35 and 8q24 with the risk of familial and early-onset breast cancer in a South-American population