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rs13281615

From SNPedia

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Make rs13281615(G;G)
ReferenceGRCh38 38.1/141
Chromosome8
Position127343372
GeneLOC101930033
is asnp
is mentioned by
dbSNPrs13281615
ebirs13281615
HLIrs13281615
Exacrs13281615
Varsomers13281615
Maprs13281615
PheGenIrs13281615
hapmaprs13281615
1000 genomesrs13281615
hgdprs13281615
ensemblrs13281615
gopubmedrs13281615
geneviewrs13281615
scholarrs13281615
googlers13281615
pharmgkbrs13281615
gwascentralrs13281615
openSNPrs13281615
23andMers13281615
23andMe allrs13281615
SNP Nexus

SNPshotrs13281615
SNPdbers13281615
MSV3drs13281615
GWAS Ctlgrs13281615
GMAF0.4826
Max Magnitude
? (A;A) (A;G) (G;G) 28
[PMID 18437204OA-icon.png] breast cancer
  • rs13281615 in 8q24 was stronger for ER-positive, PR-positive, and low grade tumors (P = 0.001, 0.011 and 10(-4), respectively) and improvement in survival after diagnosis (per-allele HR = 0.90 (0.83-0.97).

[PMID 19005751] rs13281615 confirmed in 988 sporadic breast cancer cases and 1,016 controls from the West of Ireland to be associated with increased risk (odds ratio 1.17, p(allelic) = 1.8 x 10e-2) for breast cancer

GWAS
SNP rs13281615
PubMedID [PMID 17529967OA-icon.png]
Condition Breast cancer
Gene Intergenic
Risk Allele T
pValue 5.00E-012
OR 1.08
95% CI 1.05-1.11


OMIM114480
DescBREAST CANCER
Variant
Relatedalso
[PMID 19656774OA-icon.png] Common variants in LSP1, 2q35 and 8q24 and breast cancer risk for BRCA1 and BRCA2 mutation carriers



[PMID 20145138] Common genetic variants associated with breast cancer and mammographic density measures that predict disease

[PMID 20054709] Birth weight, breast cancer susceptibility loci, and breast cancer risk

[PMID 20699374OA-icon.png] Evaluation of Breast Cancer Susceptibility Loci in Chinese Women

[PMID 21051319OA-icon.png] Risk of Urinary Bladder Cancer is Associated with 8q24 Variant rs9642880[T]: Results from the Los Angeles-Shanghai Case-Control Study

[PMID 21197568] Risk of genome-wide association study newly identified genetic variants for breast cancer in Chinese women of Heilongjiang Province


[PMID 21445572] Genetic polymorphisms and breast cancer risk: evidence from meta-analyses, pooled analyses, and genome-wide association studies


[PMID 21791674OA-icon.png] Interactions Between Genetic Variants and Breast Cancer Risk Factors in the Breast and Prostate Cancer Cohort Consortium


[PMID 21814516OA-icon.png] A Functional Variant at a Prostate Cancer Predisposition Locus at 8q24 Is Associated with PVT1 Expression


[PMID 22087758OA-icon.png] Single nucleotide polymorphisms associated with risk for contralateral breast cancer in the Women's Environment, Cancer and Radiation Epidemiology (WECARE) study


[PMID 22726230OA-icon.png] Interactive effect of genetic susceptibility with height, body mass index, and hormone replacement therapy on the risk of breast cancer


[PMID 17618282OA-icon.png] A common genetic risk factor for colorectal and prostate cancer.


[PMID 17997823OA-icon.png] Clinical correlates of low-risk variants in FGFR2, TNRC9, MAP3K1, LSP1 and 8q24 in a Dutch cohort of incident breast cancer cases.


[PMID 18224312OA-icon.png] Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.


[PMID 18349290] Association of genetic variants at 8q24 with breast cancer risk.


[PMID 18535017OA-icon.png] Pooled analysis of genetic variation at chromosome 8q24 and colorectal neoplasia risk.


[PMID 18577746OA-icon.png] Multiple loci with different cancer specificities within the 8q24 gene desert.


[PMID 18612136OA-icon.png] Discriminatory accuracy from single-nucleotide polymorphisms in models to predict breast cancer risk.


[PMID 18625567] Association of chromosomal locus 8q24 and risk of prostate cancer: a hospital-based study of German patients treated with brachytherapy.


[PMID 18681954OA-icon.png] Breast cancer susceptibility loci and mammographic density.


[PMID 18704501OA-icon.png] Comprehensive resequence analysis of a 136 kb region of human chromosome 8q24 associated with prostate and colon cancers.


[PMID 18708391OA-icon.png] Breast cancer risk polymorphisms and interaction with ionizing radiation among U.S. radiologic technologists.


[PMID 18772892OA-icon.png] Can genes for mammographic density inform cancer aetiology?


[PMID 18785201OA-icon.png] Novel breast cancer risk alleles and endometrial cancer risk.


[PMID 18973230OA-icon.png] Breast cancer susceptibility alleles and ovarian cancer risk in 2 study populations.


[PMID 19088016OA-icon.png] Genetic susceptibility loci for breast cancer by estrogen receptor status.


[PMID 19094228OA-icon.png] The influence of genetic variation in 30 selected genes on the clinical characteristics of early onset breast cancer.


[PMID 19304784OA-icon.png] Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study.


[PMID 19454617OA-icon.png] Genetic variation in the chromosome 17q23 amplicon and breast cancer risk.


[PMID 19528667OA-icon.png] Association of chromosome 8q variants with prostate cancer risk in Caucasian and Hispanic men.


[PMID 19567422OA-icon.png] Risk of estrogen receptor-positive and -negative breast cancer and single-nucleotide polymorphism 2q35-rs13387042.


[PMID 19639606OA-icon.png] Correcting "winner's curse" in odds ratios from genomewide association findings for major complex human diseases.


[PMID 20133699OA-icon.png] Long-range enhancers on 8q24 regulate c-Myc.


[PMID 20146796OA-icon.png] Familial relative risks for breast cancer by pathological subtype: a population-based cohort study.


[PMID 20237344OA-icon.png] Performance of common genetic variants in breast-cancer risk models.


[PMID 20484103OA-icon.png] Genetic and clinical predictors for breast cancer risk assessment and stratification among Chinese women.


[PMID 20605201OA-icon.png] Gene-environment interactions in 7610 women with breast cancer: prospective evidence from the Million Women Study.


[PMID 21596841OA-icon.png] Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium.


[PMID 22045194OA-icon.png] Combined effect of low-penetrant SNPs on breast cancer risk.


[PMID 22160591] A genetic risk predictor for breast cancer using a combination of low-penetrance polymorphisms in a Japanese population.


[PMID 22532573OA-icon.png] The role of genetic breast cancer susceptibility variants as prognostic factors.


GET Evidence
rs13281615
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.460317
summary



[PMID 23565189OA-icon.png] Single Nucleotide Polymorphism 8q24 rs13281615 and Risk of Breast Cancer: Meta-Analysis of More than 100,000 Cases


[PMID 23717390OA-icon.png] Identification of a Breast Cancer Susceptibility Locus at 4q31.22 Using a Genome-Wide Association Study Paradigm


[PMID 24171766OA-icon.png] Common low-penetrance risk variants associated with breast cancer in Polish women

GWAS snp
PMID [PMID 23535729OA-icon.png]
Trait Breast cancer
Title Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
Risk Allele G
P-val 1E-27
Odds Ratio 1.09 [1.07-1.12]


[PMID 22910930OA-icon.png] Genome-Wide Association Studies (GWAS) breast cancer susceptibility loci in Arabs: susceptibility and prognostic implications in Tunisians.


[PMID 22965832] Association of common genetic variants with breast cancer risk and clinicopathological characteristics in a Chinese population.


[PMID 23292077] Association of 8q24 rs13281615A > G polymorphism with breast cancer risk: evidence from 40,762 cases and 50,380 controls.


[PMID 23577780OA-icon.png] Associations between single-nucleotide polymorphisms and epidural ropivacaine consumption in patients undergoing breast cancer surgery.


[PMID 24780616] Frequent Mutation of rs13281615 and Its Association with PVT1 Expression and Cell Proliferation in Breast Cancer


[PMID 24532140] Association of genetic variants at TOX3, 2q35 and 8q24 with the risk of familial and early-onset breast cancer in a South-American population