Have questions? Visit https://www.reddit.com/r/SNPedia


From SNPedia

Make rs17561(G;G)
Make rs17561(G;T)
Make rs17561(T;T)
ReferenceGRCh38 38.1/141
is asnp
is mentioned by
1000 genomesrs17561
23andMe allrs17561
SNP Nexus

GWAS Ctlgrs17561
Max Magnitude
? (G;G) (G;T) (T;T) 28

[PMID 20157068] Association of IL1A, IL1B, and TNF Gene Polymorphisms With Chronic Rhinosinusitis With and Without Nasal Polyposis: A Replication Study

[PMID 22216303OA-icon.png] Functional Polymorphism of IL-1 Alpha and Its Potential Role in Obesity in Humans and Mice

[PMID 16642433OA-icon.png] Polymorphism in maternal LRP8 gene is associated with fetal growth.

[PMID 16820586OA-icon.png] Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.

[PMID 16842617OA-icon.png] Interleukin gene polymorphisms and breast cancer: a case control study and systematic literature review.

[PMID 16918024] Association between the interleukin-1 family gene cluster and psoriatic arthritis.

[PMID 17327408OA-icon.png] Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.

[PMID 17665434OA-icon.png] Association of interleukin-6 and interleukin-10 genotypes with radiographic damage in rheumatoid arthritis is dependent on autoantibody status.

[PMID 17705862OA-icon.png] Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.

[PMID 17932347] Polymorphisms in apoptosis- and proliferation-related genes, ionizing radiation exposure, and risk of breast cancer among U.S. Radiologic Technologists.

[PMID 18063673] Prospective meta-analysis of interleukin 1 gene complex polymorphisms confirms associations with ankylosing spondylitis.

[PMID 18454203OA-icon.png] Differential allelic expression in the human genome: a robust approach to identify genetic and epigenetic cis-acting mechanisms regulating gene expression.

[PMID 18576312OA-icon.png] A broad analysis of IL1 polymorphism and rheumatoid arthritis.

[PMID 18609743OA-icon.png] Genetics of psoriasis and psoriatic arthritis: update and future direction.

[PMID 18633131OA-icon.png] Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.

[PMID 18676870OA-icon.png] Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.

[PMID 18727828OA-icon.png] Ischemic stroke risk, smoking, and the genetics of inflammation in a biracial population: the stroke prevention in young women study.

[PMID 18838388] Interleukin-1 promoter region polymorphism role in rheumatoid arthritis: a meta-analysis of IL-1B-511A/G variant reveals association with rheumatoid arthritis.

[PMID 18978339OA-icon.png] Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity.

[PMID 19035492OA-icon.png] Cytokine gene polymorphisms as risk and severity factors for juvenile dermatomyositis.

[PMID 19043479OA-icon.png] Association of -31T>C and -511 C>T polymorphisms in the interleukin 1 beta (IL1B) promoter in Korean keratoconus patients.

[PMID 19066394OA-icon.png] Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.

[PMID 19356949OA-icon.png] Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.

[PMID 19468064OA-icon.png] Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions.

[PMID 19934104OA-icon.png] Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations.

[PMID 20113413] Cytokine polymorphism in patients with migraine: some suggestive clues of migraine and inflammation.

[PMID 20192980] The interleukin-1 cluster gene region is associated with multiple sclerosis in an Italian Caucasian population.

[PMID 20459687OA-icon.png] Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring.

[PMID 20725607OA-icon.png] CCL3 genotype and current depression increase risk of HIV-associated dementia.

[PMID 20811626OA-icon.png] Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.

[PMID 21279638] Coding single-nucleotide polymorphisms of interleukin-1 gene cluster are not associated with Kawasaki disease in the Korean population.

[PMID 21621860] Association of IL1A, IL1B, ILRN, IL6, IL10 and TNF-alpha polymorphisms with risk and clinical course of multiple sclerosis in a Polish population.

[PMID 22282663OA-icon.png] Ovarian cancer risk associated with inherited inflammation-related variants.

GET Evidence
aa_change Ala114Ser
aa_change_short A114S
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.259063

[PMID 22723975OA-icon.png] Polymorphisms in RYBP and AOAH genes are associated with chronic rhinosinusitis in a Chinese population: a replication study

[PMID 23927441OA-icon.png] Genetic variants in IL1A and IL1B contribute to the susceptibility to 2009 pandemic H1N1 influenza A virus

[PMID 24272484OA-icon.png] Risk of Ovarian Cancer and the NF-κB Pathway: Genetic association with IL1A and TNFSF10

[PMID 21962386] The associations between interleukin-1 polymorphisms and susceptibility to ankylosing spondylitis: a meta-analysis.

[PMID 23459936OA-icon.png] Exploring the genetic basis of chronic periodontitis: a genome-wide association study.

[PMID 24862933] Association of an insertion/deletion polymorphism in IL1A 3'-UTR with risk for cervical carcinoma in Chinese Han Women

[PMID 25902400] Polymorphisms in the inflammatory pathway genes and the risk of preeclampsia in Sinhalese women

[PMID 26391153] Polymorphisms in host immune response associated genes and risk of nasopharyngeal carcinoma development in Portugal

[PMID 26448013OA-icon.png] High Incidence of Malaria Along the Sino-Burmese Border Is Associated With Polymorphisms of CR1, IL-1A, IL-4R, IL-4, NOS, and TNF, But Not With G6PD Deficiency

[PMID 24918527OA-icon.png] Genetic variations in IL1A and IL1RN are associated with the risk of preeclampsia in Chinese Han population