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rs1898830

From SNPedia

Orientationplus
Stabilizedplus
Make rs1898830(A;A)
Make rs1898830(A;G)
Make rs1898830(G;G)
ReferenceGRCh38 38.1/141
Chromosome4
Position153687301
GeneTLR2
is asnp
is mentioned by
dbSNPrs1898830
ebirs1898830
HLIrs1898830
Exacrs1898830
Varsomers1898830
Maprs1898830
PheGenIrs1898830
hapmaprs1898830
1000 genomesrs1898830
hgdprs1898830
ensemblrs1898830
gopubmedrs1898830
geneviewrs1898830
scholarrs1898830
googlers1898830
pharmgkbrs1898830
gwascentralrs1898830
openSNPrs1898830
23andMers1898830
23andMe allrs1898830
SNP Nexus

SNPshotrs1898830
SNPdbers1898830
MSV3drs1898830
GWAS Ctlgrs1898830
GMAF0.3466
Max Magnitude
? (A;A) (A;G) (G;G) 28
rs1898830, known as -15607A/G and located in the first intron of the TLR2 gene, is associated with an increased risk for shedding and lesion frequency of genital herpes simplex virus type 2 HSV-2 outbreaks.[PMID 17624834]

The risk allele is (G).

Note that the increased risk is not that great; median shedding rate was 16.7% for (G) allele carriers vs 12.0% when it was absent (= risk ratio for a dominant effect of 1.60), and the median lesional rate was 10.4% for (G) carriers vs 5.3% for non-carriers (risk ratio 2.16). [PMID 17624834]


[PMID 20577149] IDENTIFICATION OF HAPLOTYPE TAG SNPS WITHIN THE ENTIRE TLR2 GENE AND THEIR CLINICAL RELEVANCE IN PATIENTS WITH MAJOR TRAUMA


[PMID 21371045] TLR2 polymorphisms influence neonatal regulatory T cells depending on maternal atopy


[PMID 18396467OA-icon.png] Genetic variation and haplotype structures of innate immunity genes in eastern India.


[PMID 19543401OA-icon.png] Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women.


[PMID 20057905OA-icon.png] Association of toll-like receptor 2 gene polymorphisms with normal tension glaucoma.


[PMID 20113509OA-icon.png] Toll-like receptor 2 gene polymorphisms, pulmonary tuberculosis, and natural killer cell counts.


[PMID 20227302] Polymorphisms in innate immunity genes associated with development of bronchiolitis obliterans after lung transplantation.


[PMID 21437199OA-icon.png] Toll-like receptor 2 (TLR2) gene polymorphisms are not associated with sarcoidosis in the Japanese population.


[PMID 23657238OA-icon.png] Toll-like receptor-associated sequence variants and prostate cancer risk among men of African descent


[PMID 23021866OA-icon.png] Toll-like receptor gene variants associated with bacterial vaginosis among HIV-1 infected adolescents


[PMID 23906542] Polymorphisms in TLR-2 are associated with congenital cytomegalovirus (CMV) infection but not with congenital CMV disease


[PMID 23161283OA-icon.png] SNPs in toll-like receptor (TLR) genes as new genetic alterations associated with congenital toxoplasmosis?


[PMID 25928077OA-icon.png] Screening toll-like receptor markers to predict latent tuberculosis infection and subsequent tuberculosis disease in a Chinese population