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rs20576

From SNPedia

Orientationminus
Stabilizedminus
Make rs20576(A;A)
Make rs20576(A;C)
Make rs20576(C;C)
ReferenceGRCh38 38.1/141
Chromosome8
Position23200707
GeneTNFRSF10A
is asnp
is mentioned by
dbSNPrs20576
ebirs20576
HLIrs20576
Exacrs20576
Varsomers20576
Maprs20576
PheGenIrs20576
hapmaprs20576
1000 genomesrs20576
hgdprs20576
ensemblrs20576
gopubmedrs20576
geneviewrs20576
scholarrs20576
googlers20576
pharmgkbrs20576
gwascentralrs20576
openSNPrs20576
23andMers20576
23andMe allrs20576
SNP Nexus

SNPshotrs20576
SNPdbers20576
MSV3drs20576
GWAS Ctlgrs20576
GMAF0.1065
Max Magnitude
? (A;A) (A;C) (C;C) 28
Carriers of an 228Ala allele for rs20576 who have prostate cancer and are treated by radiation therapy have a higher risk (odds ratio 2.47, CI: 1.10-5.54, p=0.028) for subsequent metastasis. [PMID 18163425]


[PMID 19643596] TRAIL-R1 polymorphisms and cancer susceptibility: An evidence-based meta-analysis


[PMID 21484799] Association of death receptor 4 variant (683A > C) with ovarian cancer risk in BRCA1 mutation carriers.


GET Evidence
TNFRSF10A-E228A
aa_change Glu228Ala
aa_change_short E228A
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.145566
summary



[PMID 23658636OA-icon.png] Candidate Gene Study of TRAIL and TRAIL Receptors: Association with Response to Interferon Beta Therapy in Multiple Sclerosis Patients


[PMID 24587306OA-icon.png] Death Receptor (DR4) Haplotypes Are Associated with Increased Susceptibility of Gallbladder Carcinoma in North Indian Population


[PMID 25207117OA-icon.png] A Study of the Impact of Death Receptor 4 (DR4) Gene Polymorphisms in Alzheimer's Disease