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rs2227631

From SNPedia

Orientationplus
Stabilizedplus
Make rs2227631(A;A)
Make rs2227631(A;G)
Make rs2227631(G;G)
ReferenceGRCh38 38.1/141
Chromosome7
Position101126257
GeneSERPINE1
is asnp
is mentioned by
dbSNPrs2227631
ebirs2227631
HLIrs2227631
Exacrs2227631
Varsomers2227631
Maprs2227631
PheGenIrs2227631
hapmaprs2227631
1000 genomesrs2227631
hgdprs2227631
ensemblrs2227631
gopubmedrs2227631
geneviewrs2227631
scholarrs2227631
googlers2227631
pharmgkbrs2227631
gwascentralrs2227631
openSNPrs2227631
23andMers2227631
23andMe allrs2227631
SNP Nexus

SNPshotrs2227631
SNPdbers2227631
MSV3drs2227631
GWAS Ctlgrs2227631
GMAF0.4408
Max Magnitude
? (A;A) (A;G) (G;G) 28
[PMID 21752301OA-icon.png] Significant associations of PAI-1 genetic polymorphisms with osteonecrosis of the femoral head


[PMID 22133274OA-icon.png] Polymorphisms of PAI-1 and platelet GP Ia may associate with impairment of renal function and thrombocytopenia in Puumala hantavirus infection


[PMID 16172282] Comprehensive survey of common genetic variation at the plasminogen activator inhibitor-1 locus and relations to circulating plasminogen activator inhibitor-1 levels.


[PMID 16424345] Plasminogen activator inhibitor-1 gene: selection of tagging single nucleotide polymorphisms and association with coronary heart disease.


[PMID 17656673] Association of plasminogen activator inhibitor (PAI)-1 (SERPINE1) SNPs with myocardial infarction, plasma PAI-1, and metabolic parameters: the HIFMECH study.


[PMID 18853133OA-icon.png] Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.


[PMID 18974842OA-icon.png] Gender differences in genetic risk profiles for cardiovascular disease.


[PMID 19360663OA-icon.png] Genetic evidence implicating multiple genes in the MET receptor tyrosine kinase pathway in autism spectrum disorder.


[PMID 19368854] No association between the promoter polymorphisms of PAI-1 gene and sporadic Alzheimer's disease in Chinese Han population.


[PMID 19526059OA-icon.png] Polymorphic variation of genes in the fibrinolytic system and the risk of ovarian cancer.


[PMID 22503724] Promoter polymorphisms of SERPINE1 are associated with the antidepressant response to depression in Alzheimer's disease.


GET Evidence
rs2227631
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.555556
summary



GWAS snp
PMID [PMID 22990020OA-icon.png]
Trait Plasminogen activator inhibitor type 1 levels (PAI-1)
Title Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation.
Risk Allele
P-val 3E-24
Odds Ratio .07 [NR] unit increase


[PMID 24135164OA-icon.png] Genetic polymorphisms in plasminogen activator inhibitor-1 predict susceptibility to steroid-induced osteonecrosis of the femoral head in Chinese population


[PMID 24355042] Association of five common polymorphisms in the plasminogen activator inhibitor-1 gene with primary ovarian insufficiency


[PMID 25231632] Pai-1 Gene Variants and COC Use Are Associated with Stroke Risk: A Case-Control Study in the Han Chinese Women


[PMID 27510778] [Association of single nucleotide polymorphisms in PAI-1 with breast cancer susceptibility and prognosis].