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rs314277

From SNPedia

Orientationplus
Stabilizedplus
Make rs314277(A;A)
Make rs314277(A;C)
Make rs314277(C;C)
ReferenceGRCh38 38.1/141
Chromosome6
Position104959787
GeneLIN28B
is asnp
is mentioned by
dbSNPrs314277
ebirs314277
HLIrs314277
Exacrs314277
Varsomers314277
Maprs314277
PheGenIrs314277
hapmaprs314277
1000 genomesrs314277
hgdprs314277
ensemblrs314277
gopubmedrs314277
geneviewrs314277
scholarrs314277
googlers314277
pharmgkbrs314277
gwascentralrs314277
openSNPrs314277
23andMers314277
23andMe allrs314277
SNP Nexus

SNPshotrs314277
SNPdbers314277
MSV3drs314277
GWAS Ctlgrs314277
GMAF0.197
Max Magnitude
? (A;A) (A;C) (C;C) 28
GWAS snp
PMID [PMID 18391950OA-icon.png]
Trait Height
Title Identification of ten loci associated with height highlights new biological pathways in human growth
Risk Allele A
P-val 1E-8
Odds Ratio 0.41 [0.26-0.59] cm taller
GWAS snp
PMID [PMID 19448621OA-icon.png]
Trait Menarche and menopause (age at onset)
Title Genome-wide association studies identify loci associated with age at menarche and age at natural menopause
Risk Allele A
P-val 3E-13
Odds Ratio 0.16 [0.12-0.20] years older
GWAS snp
PMID [PMID 20303062OA-icon.png]
Trait Digit length ratio
Title A Variant in LIN28B Is Associated with 2D:4D Finger-Length Ratio, a Putative Retrospective Biomarker of Prenatal Testosterone Exposure
Risk Allele A
P-val 0.000002
Odds Ratio 0.63 [0.41-0.85] increase in mean 2D:4D
OMIM136100
DescFINGERS, RELATIVE LENGTH OF
Variant
Relatedalso
OMIM606255
Desc
Variant
Relatedalso
OMIM612882
Desc
Variant
Relatedalso


[PMID 22822098] Functional Study of Risk Loci of Stem Cell-associated Gene Lin-28B and Associations with Disease Survival Outcomes in Epithelial Ovarian Cancer


[PMID 19030899OA-icon.png] Genome-wide association scan for stature in Chinese: evidence for ethnic specific loci.


[PMID 19448622] Genome-wide association study identifies sequence variants on 6q21 associated with age at menarche.


[PMID 20398887OA-icon.png] Distinct variants at LIN28B influence growth in height from birth to adulthood.


GET Evidence
rs314277
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.757812
summary



[PMID 23508249OA-icon.png] Replication of genetic loci for ages at menarche and menopause in the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) study